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Allosteric Site definition: A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
allosteric site definition: enzyme site which binds molecule other than substrate, thereby regulating enzyme activity.
Attachment Sites, Microbiological definition: Specific loci on both the bacterial DNA (attB) and the phage DNA (attP) which delineate the sites where recombination takes place between them, as the phage DNA becomes integrated (inserted) into the BACTERIAL DNA during LYSOGENY.
Binding Sites definition: The parts of a macromolecule that directly participate in its specific combination with another molecule.
binding site definition: reactive portion of a macromolecule that directly participates in its specific combination with another molecule.
Binding Sites, Antibody definition: Local surface sites on antibodies which react with antigen determinant sites on antigens. They are formed from parts of the variable regions of FAB FRAGMENTS.
Antibody Binding Site definition: The site at which an antibody makes direct physical contact with a corresponding epitope on an antigen.
Neoplasms by Site definition: A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.
cholinergic receptor definition: since the 2 subtypes are distinctly different receptors, use MUSCARINIC or NICOTINIC whenever possible; use this general term only for unspecified binding of acetylcholine and related ligands.
Receptors, Cholinergic definition: Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.
Receptors, Concanavalin A definition: Glycoprotein moieties on the surfaces of cell membranes that bind concanavalin A selectively; the number and location of the sites depends on the type and condition of the cell.
Immunodominant Epitopes definition: Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody.
Workplace definition: Place or physical location of work or employment.
work site definition: location or environment where an individual is employed; e.g. office, laboratory, building, warehouse, etc.
Worksite definition: Place or physical location of work or employment.
work place definition: An office address. First choice for business related contacts during business hours.
Site definition: A position in relation to its surroundings.
active site definition: molecular location on an enzyme where substrate binds and catalysis occurs.
Active Site definition: The catalytic site of an enzyme, the part of an enzyme where the actual enzymatic function is performed.
Chromosome Fragile Sites definition: Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Chromosome Fragile Site definition: Heritable sensitive regions of chromosomes which show up in vitro as non-staining bands. They are associated with chromosome breakage and other aberrations. No abnormal phenotype has been definitely identified with autosomal fragile sites, but some rare autosomal recessive disorders may be due to homozygosity for fragile sites. A fragile site on the X chromosome is associated with Fragile X Syndrome. Fragile sites are designated by the letters "fra" followed by the designation for the specific chromosome and locus.
Wound Care definition: Actions performed to support open skin areas.
E-Box Elements definition: DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.
All Sites definition: Anything relevant to all anatomic sites - non-specific.
Anatomic Site definition: Named locations of or within the body.