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Definition
 
enEnglish
Antibody Specificity definition: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
antibody specificity definition: property of antibodies which enables them to react with some antigenic determinants and not with others; specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Organ Specificity definition: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Sensitivity and Specificity definition: Measures for assessing the results of diagnostic and screening tests. Sensitivity represents the proportion of truly diseased persons in a screened population who are identified as being diseased by the test. It is a measure of the probability of correctly diagnosing a condition. Specificity is the proportion of truly nondiseased persons who are so identified by the screening test. It is a measure of the probability of correctly identifying a nondiseased person. (From Last, Dictionary of Epidemiology, 2d ed)
Species Specificity definition: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Substrate Specificity definition: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Dual Specificity Phosphatase 1 definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Cell Division Cycle 2-Like 1 definition: Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)
Cleavage And Polyadenylation Specificity Factor definition: An RNA-binding protein that recognizes the AAUAAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Cyclin-Dependent Kinase Inhibitor 3 definition: Cyclin-Dependent Kinase Inhibitor 3, encoded by the CDKN3 gene, is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)
Dual Specificity Phosphatase 2 definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CELL NUCLEUS.
Dual Specificity Phosphatase 1 definition: Dual Specificity Phosphatase 1, encoded by the DUSP1 gene, is induced by oxidative stress and heat shock. This protein specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. (from LocusLink and Swiss-Prot)
Dual Specificity Phosphatase 6 definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CYTOSOL.
Cell Division Cycle 25A Protein definition: Cell Division Cycle 25A Protein (CDC25A), encodes by the CDC25A gene, is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. The CDC25A gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary)
T-Cell Antigen Receptor Specificity definition: The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.
CDKN3 Gene definition: This gene plays a role in cell cycle regulation.
DUSP1 Gene definition: This gene is a transcriptional target of TP53 protein and plays a role in cell cycle regulation.
DUSP3 Gene definition: This gene plays a role in the inactivation of proteins involved in cellular differentiation and proliferation.
Dual-Specificity Phosphoprotein Phosphatase definition: Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of signalling pathways that are involved in cell stress responses, proliferation and death. (from Nat Rev Drug Discov 2002;1:961-76)
Dual Specificity Phosphatase 3 definition: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES.
Dual Specificity Phosphatase 3 definition: Encoded by human DUSP3 Gene, 185-amino acid 20.5 kD conserved VH1-Related Phosphatase is a non-receptor member of the dual specificity protein phosphatase subfamily (Protein-Tyrosine Phosphatase Family) that inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERK, SAPK/JNK, and p38 members associated with cellular proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct substrate specificities for MAP kinases, and different modes of induction by extracellular stimuli. (from Swiss-Prot, OMIM, and NCI)
SP1 Gene definition: This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways.
DUSP22 Gene definition: This gene is involved in the inactivation of proteins which participate in cellular differentiation and proliferation.
Diagnostic Specificity definition: The probability that a test will produce a true negative result when used on non-effected subjects as compared to a reference or "gold standard". The specificity of a test can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false positive results.
Diagnostic Specificity definition: The probability that an individual who does not have a particular condition is classified as not diseased as a result of diagnostic evaluation.
Dual Specificity Phosphatase 22 definition: Dual Specificity Phosphatase 22 (184-aa 21-kDa) is encoded by human MKPX Gene. While MAP kinases play a pivotal role in cellular signal transduction, dual-specificity phosphatases can reverse MAP kinase activation by dephosphorylating critical phosphotyrosine and phosphothreonine residues. (NCI)
Sp Transcription Factors definition: A family of DNA-binding proteins that contain three ZINC FINGERS at their carboxy termini. They are transcription factors that have specificity for GC boxes.
Dual-Specificity Phosphatases definition: A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.
specificity definition: Spécificité.
 
 
frFrench
spécificité definition: Caractère spécifique de quelque chose, caractère qui est propre spécialement à quelque chose.
spécificité definition: Probabilité, dans un test binaire, d'identifier correctement un vrai négatif.