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Gastric Balloons, Appetite-Suppressing definition: Devices that are inserted into the stomach in order to inflate within the stomach and thereby reduce the desire for food. The devices are in the form of a balloon, inserted by catheter and remain until such time as the desired effect is accomplished. The device is usually made of a polymer material. Certain types degrade over a period of time.
Genes, Tumor Suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
tumor suppressor gene definition: genes whose loss or deactivation leads to neoplastic transformation; compare with ONCOGENE and PROTOONCOGENE.
tumor suppressor gene definition: (TOO-mer) Genes in the body that can suppress or block the development of cancer.
Tumor Suppressor Gene definition: Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI)
Tumor Suppressing Subtransferable Candidate 5 Protein definition: Expressed predominantly in fetal and adult liver and kidney by human SLC22A1L Gene (Polyspecific Transporter/MDR Family), 424-aa Tumor Suppressing Subtransferable Candidate 5 Protein (Organic Cation Transporter-Like 2 Protein) is a polyspecific organic-cation transporter, containing 10 transmembrane segments, involved in excretion of endogenous and exogenous compounds. SLC22A1L translation may begin at the second methionine, which would result in a 408-amino acid protein. (NCI)
Tumor Suppressing Subtransferable Candidate 1 Protein definition: Encoded by human TSSC1 Gene, 387-amino acid 44 kD Tumor Suppressing Subtransferable Candidate 1 Protein is similar to Rb-Associated Protein p48 and chromatin assembly factor CAF1. The gene is located in an imprinted domain associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. (from Swiss-Prot and NCI)
PHEMX Protein definition: Encoded by human PHEMX Gene, 320-amino acid 34.6 kD ubiquitous TSSC6 Protein (Tetraspanin Family) is an integral membrane protein of 290 amino acids that shows no similarity to any reported protein and may play a role in hematopoietic cell function. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus, and spleen. Alterations in TSSC6 Protein or its gene may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer. (from SWISS-PROT, OMIM, and NCI)
tetraspanin definition: cell surface proteins that span the membrane four times and are found on many different cell types in many organisms; form cell surface complexes with other molecules participating in cell adhesion, either to the extracellular matrix (ECM) or to other cells, and with molecules required for signaling; also called tetraspans or the transmembrane 4 superfamily (TM4SF).
TSPAN32 Gene definition: This gene is associated with several disease entities, however an exact function has not been elucidated. The gene may play a role in malignancies and hematopoietic cell function.
PHLDA2 Gene definition: This gene is putatively involved in the regulation of placental growth.
TSSC1 Gene definition: This gene plays a role in the regulation of transcription.
Tumor Suppressing Subtransferable Candidate 3 Protein definition: Encoded by human TSSC3 Gene, 152-amino acid 17 kD TSSC3 Protein is expressed in fetal and adult liver, lung, and kidney, placenta, and adult pancreas. With similarity to TDAG51, essential for FAS expression and susceptibility to apoptosis, TSSC3 may be involved in susceptibility to apoptosis. Mouse Tssc3 encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. (from Swiss-Prot, OMIM, and NCI)
TSSC4 Gene definition: This gene is involved in transcriptional regulation, genetic imprinting and silencing.
SLC22A18 Gene definition: This gene plays a role in organic-cation transport and alterations in the gene have been associated with several cancers.
TSSC4 Protein definition: Encoded by human TSSC4 Gene, the 329-amino acid 34 kD TSSC4 Protein shows no close similarity to previously reported proteins and is expressed in fetal brain, lung, liver, and kidney. Alterations in TSSC4 may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer. (from SWISS-PROT, OMIM, and NCI)
TSPAN32 wt Allele definition: Human TSPAN32 wild-type allele is located in the vicinity of 11p15.5 and is approximately 16 kb in length. This allele, which encodes tetraspanin-32 protein, is involved in tumor suppression and may play a role in hematopoietic cell function.
TSSC4 wt Allele definition: Human TSSC4 wild-type allele is located in the vicinity of 11p15.5 and is approximately 3 kb in length. This allele, which encodes protein TSSC4, is putatively involved in the inhibition of cell growth. The TSSC4 gene is located in a chromosomal region that is important with respect to tumor suppression. Alterations in this region are associated with many types of cancer such as breast, lung and ovarian cancers.
TSSC1 wt Allele definition: Human TSSC1 wild-type allele is located in the vicinity of 2p25.3 and is approximately 189 kb in length. This allele, which encodes protein TSSC1, plays a role in the organization of chromatin.