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beta-Thromboglobulin definition: A platelet-specific protein which is released when platelets aggregate. Elevated plasma levels have been reported after deep venous thrombosis, pre-eclampsia, myocardial infarction with mural thrombosis, and myeloproliferative disorders. Measurement of beta-thromboglobulin in biological fluids by radioimmunoassay is used for the diagnosis and assessment of progress of thromboembolic disorders.
Beta Thromboglobulin definition: Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Upon platelet activation, PBP is proteolytically converted to Beta Thromboglobulin, a homotetramer released when platelets aggregate. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. CTAP-III is also proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)
Platelet Factor 4 definition: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
platelet factor 4 definition: high molecular weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin; acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation.
Platelet Factor 4 definition: Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)
Recombinant Platelet Factor 4 definition: A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types.
Reagents, Hematology, Coagulation, Thrombophilia Marker, Beta-Thromboglobulin definition: Hematology reagents used for qualitative and/or quantitative determination in plasma of thromboglobulin, a platelet-specific protein that is usually released simultaneously with platelet factor 4. Beta-thromboglobulin binds and inactivates heparin and blocks the release of prostacyclin; increased levels in blood may indicate the occurrence of thrombosis (i.e., it is considered a thrombophilia marker).
PPBP Gene definition: This gene plays a variety of roles in cellular processes such as extracellular matrix synthesis, glucose metabolism, and megakaryocyte differentiation.
Recombinant Beta Thromboglobulin definition: A therapeutic analogue of an endogenous, platelet-specific protein that is a member of the alpha chemokine family. Beta thromboglobulin may be used as a marker for platelet activation. (NCI04)