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Definition
 
enEnglish
Conserved Helix-Loop-Helix Ubiquitous Kinase definition: Widely expressed by human CHUK Gene (Ser/Thr IKBK Family), 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase is an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)
CHUK Gene definition: This gene plays a role in signal transduction and regulation of transcription.
CHUK wt Allele definition: Human CHUK wild-type allele is located within 10q24-q25 and is approximately 80 kb in length. This allele, which encodes inhibitor of nuclear factor kappa-B kinase subunit alpha protein, is involved in the progression of nuclear factor kappa B complex signaling.
 
 
deGerman
ubiquitär definition: [1] allgegenwärtig, überall verbreitet