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Phleomycin induces DNA breakage in vitro in the presence of the sulphydryl compound dithiothreitol.

M J Sleigh

Nucleic Acids Research 3 (4), 01 Apr 1976

Reaction rate is limited by the concentration of oxygen, which is converted to hydrogen peroxide during DNA breakage.

M J Sleigh

Nucleic Acids Research 3 (4), 01 Apr 1976

Free phleomycin is converted to an inactive form, but activation of phleomycin bound to DNA leads to DNA breakage.

M J Sleigh

Nucleic Acids Research 3 (4), 01 Apr 1976

For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative “fragile breakage” model of chromosome evolution.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

In 2004, Sankoff and Trinh argued against the fragile breakage model and raised doubts that Pevzner and Tesler provided any evidence of rearrangement hot spots.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

We further argue that if Sankoff and Trinh had fixed these problems, their arguments in support of the random breakage model would disappear.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative “fragile breakage” model of chromosome evolution.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

In 2004, Sankoff and Trinh performed a series of computational simulations that argued against the fragile breakage model and raised doubts that Pevzner and Tesler provided any evidence of rearrangement hot spots.

Qian Peng et al.

PLoS Computational Biology 2 (2), 01 Feb 2006

In vitro, CTT enhances the breakage of DNA by topo I when the reaction is stopped with detergent.

S E Porter et al.

Nucleic Acids Research 17 (21), 11 Nov 1989

Although breakage at some sites is enhanced to a great extent while breakage at others is enhanced only minimally, CTT does not significantly change the breakage specificity of topo I in vitro.

S E Porter et al.

Nucleic Acids Research 17 (21), 11 Nov 1989

In support of the hypothesis, we find that topo I-mediated DNA breakage is enhanced the greatest at those sites where closure of the break is the slowest.

S E Porter et al.

Nucleic Acids Research 17 (21), 11 Nov 1989

Tel: +1 206 667 5005; Fax: +1 206 667 6526; Email: mcyao@fhcrc.org 15 2 2000 28 4 895 900 29 10 1999 13 12 1999 13 12 1999 Copyright © 2000 Oxford University Press 2000 Programmed chromosome breakage occurs at 50–200 specific sites in the genome of Tetrahymena thermophila during somatic nuclear (macronuclear) differentiation.

Qichang Fan et al.

Nucleic Acids Research 28 (4), 15 Feb 2000

Previous studies have identified a 15 bp sequence, the Cbs (for chromosome breakage sequence), that is necessary and sufficient to specify these sites.

Qichang Fan et al.

Nucleic Acids Research 28 (4), 15 Feb 2000

In this study we determined the effects of mutations in the Cbs on its ability to specify the chromosome breakage site and promote new telomere formation in conjugating cells.

Qichang Fan et al.

Nucleic Acids Research 28 (4), 15 Feb 2000

Fourteen of them (covering 11 positions) abolished breakage entirely, six (covering six positions, including the remaining four) caused partial loss of breakage function and one showed no detectable effect.

Qichang Fan et al.

Nucleic Acids Research 28 (4), 15 Feb 2000

In addition, we found that a partially functional Cbs retained in the macronucleus does not induce chromosome breakage during vegetative growth and that excess copies of this germline-specific sequence in the somatic nucleus have little deleterious effect on cell growth.

Qichang Fan et al.

Nucleic Acids Research 28 (4), 15 Feb 2000

Products formed from defined oligodeoxyribonucleotide tetramers (oligonucleotides) by depurination at pH 5.0 and 90 degrees C followed by chain breakage at the resulting apurinic sites (AP sites) were assigned by reversed phase HPLC.

T Suzuki et al.

Nucleic Acids Research 22 (23), 25 Nov 1994

Through kinetic analysis, rate constants of depurination and subsequent chain breakage reactions were measured.

T Suzuki et al.

Nucleic Acids Research 22 (23), 25 Nov 1994

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