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One particularly important use of epidemiological studies is to validate (or invalidate) the laboratory animal experiments.

D P Rall

Environmental Health Perspectives 32 (7), 01 Oct 1979

There is no more powerful tool than the combination of well conducted animal experiments and well conducted epidemiological experiments.

D P Rall

Environmental Health Perspectives 32 (7), 01 Oct 1979

However, a recent large-scale systematic review indicates that invasive chimpanzee experiments rarely provide benefits in excess of their profound animal welfare, bioethical and financial costs.

Andrew Knight

Philosophy, ethics, and humanities in medicine : PEHM 3 (7), 02 Jun 2008

The approval of large numbers of these experiments – particularly within the US – therefore indicates a failure of the ethics committee system.

Andrew Knight

Philosophy, ethics, and humanities in medicine : PEHM 3 (7), 02 Jun 2008

In continuing to conduct such experiments on chimpanzees and other great apes, the US was almost completely isolated internationally.

Andrew Knight

Philosophy, ethics, and humanities in medicine : PEHM 3 (7), 02 Jun 2008

Although around half a dozen other countries also conducted chimpanzee experiments 15 years ago, by 2008 the US stood virtually alone.

Andrew Knight

Philosophy, ethics, and humanities in medicine : PEHM 3 (7), 02 Jun 2008

This concern has contributed to a growing number of national bans against invasive experiments on great apes.

Andrew Knight

Philosophy, ethics, and humanities in medicine : PEHM 3 (7), 02 Jun 2008

In such experiments, the most frequently used dyes are Cy 3 and Cy 5.

Marie-Laure Martin-Magniette et al.

BMC Bioinformatics 9 (7), 28 Apr 2008

The triple-target or four-target technology is very promising, since it allows more flexibility in the design of experiments, an increase in the statistical power when comparing gene expressions induced by different conditions and a scaled down number of slides.

Marie-Laure Martin-Magniette et al.

BMC Bioinformatics 9 (7), 28 Apr 2008

Moreover the lowess correction of the global dye effect is available for only two-color experiments, and even if its application can be derived, it does not allow simultaneous correction of the raw data.

Marie-Laure Martin-Magniette et al.

BMC Bioinformatics 9 (7), 28 Apr 2008

We propose a two-step normalization procedure for triple-target experiments.

Marie-Laure Martin-Magniette et al.

BMC Bioinformatics 9 (7), 28 Apr 2008

The normalization procedure is validated using triple-self experiments and by comparing the results of triple-target and two-color experiments.

Marie-Laure Martin-Magniette et al.

BMC Bioinformatics 9 (7), 28 Apr 2008

Results We present an approach for the global validation of DNA microarray experiments that will allow researchers to evaluate the general quality of their experiment and to extrapolate validation results of a subset of genes to the remaining non-validated genes.

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

We provide recommendations that will enhance validity checks of microarray experiments while minimizing the need to run a large number of labour-intensive individual validation assays.

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

Moreover, public repositories of microarray experiments contain an ever increasing number of archived studies for which it is not readily possible to evaluate the quality.

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

Global validation of microarray experiments is necessary to address these shortcomings.

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

Such an approach would be a valuable tool for investigators to assess the value of their microarray experiments.

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

Furthermore, if routinely provided in archived gene expression experiments, global validation information would identify studies most useful for hypothesis generation and would also provide a study confidence index that could be used for several applications including meta-analysis [ 4 ] and Bayesian network modelling [ 5 ].

Mathieu Miron et al.

BMC Bioinformatics 7 (7), 05 Jul 2006

In DNA microarray experiments, measurements from different biological samples are often assumed to be independent and to have identical variance.

Anders Sjögren et al.

BMC Bioinformatics 8 (7), 15 Oct 2007

The current version of WAME is, however, limited to experiments with paired design, e.g. two-channel microarrays.

Anders Sjögren et al.

BMC Bioinformatics 8 (7), 15 Oct 2007

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