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Lung tissue slices are model systems for the study of pulmonary metabolism.

B A Freeman et al.

Environmental Health Perspectives 56 (7), 01 Jun 1984

Because of the speed and simplicity of slice preparation, lung slices have been used in studies of oxygen, amino acid, carbohydrate and lipid utilization and adenine nucleotide metabolism.

B A Freeman et al.

Environmental Health Perspectives 56 (7), 01 Jun 1984

Lung slices prepared from animals exposed to oxidant air pollutants exhibit alterations in respiration, glucose consumption and lipid metabolism.

B A Freeman et al.

Environmental Health Perspectives 56 (7), 01 Jun 1984

The uptake/accumulation and interaction of CdCl2, HgCl2, K2Cr2O7, and NaAsO2 was examined in precision-cut rabbit renal cortical slices.

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

Slices were incubated with 10(-6) to 10(-3) M of a single metal toxicant or combinations of metal toxicants for 12 hr in DME-F12 media.

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

Slices were blotted and sandwiched between two mylar films stretched across XRF sample cups.

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

Quantitation of the metal in the slices was performed by proton-induced X-ray emission analysis (PIXE).

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

When two metals were present together, substantial alterations were observed in the uptake of the metals in the slices.

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

PIXE analysis of metal content in slices is attractive since all elements (atomic number > 20) can be determined simultaneously.

R L Keith et al.

Environmental Health Perspectives 103 (Suppl 1), 01 Feb 1995

We have studied airway and vascular responses in rat lung slices and separately in vitro using myography.

L Moreno et al.

Respiratory Research 7 (1), 2006

In lung slices, under basal conditions, acetylcholine contracted airways, but had no vascular effect.

L Moreno et al.

Respiratory Research 7 (1), 2006

Airway responses in lung slices were unaffected by L-N G nitro-L-arginine methyl ester, indomethacin or apamin plus charybdotoxin.

L Moreno et al.

Respiratory Research 7 (1), 2006

Our observations are the first to identify mechanisms of endothelium dependent dilations in precision cut lung slices and the potential for transverse hormonal communication between airways and vessels.

L Moreno et al.

Respiratory Research 7 (1), 2006

In addition, some groups have investigated tonic responses in airways [ 6 - 9 ]) or pulmonary vessels [ 10 , 11 ] in situ in whole lung slices using agonists.

L Moreno et al.

Respiratory Research 7 (1), 2006

Methods applied to study airway and vascular responses in the whole lung slices rely on the infusion of a scaffold material such as agarose to facilitate the efficient sectioning of the tissue.

L Moreno et al.

Respiratory Research 7 (1), 2006

Functional endothelial-dependent responses have been demonstrated in arteries and veins of guinea-pig lung slices, although comparisons with airway responses have not been made [ 12 ].

L Moreno et al.

Respiratory Research 7 (1), 2006

In the current study we have measured the contractile and relaxant responses of airways and vessels in situ in whole lung slices using video microscopy [ 13 ].

L Moreno et al.

Respiratory Research 7 (1), 2006

Finally, in each case, we have compared responses of vessels and airways in whole lung slices with those obtained using isolated structures in in vitro using wire myographs.

L Moreno et al.

Respiratory Research 7 (1), 2006

We used cultured rabbit renal slices as the biological system to demonstrate the use of PIXE analysis.

T Lowe et al.

Environmental Health Perspectives 101 (4), 01 Sep 1993

The renal slices were exposed to HgCl2, CdCl2, K2Cr2O7, or NaAsO2 alone or in a mixture.

T Lowe et al.

Environmental Health Perspectives 101 (4), 01 Sep 1993

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