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Cladribine definition: An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
cladribine definition: An anticancer drug that belongs to the family of drugs called antimetabolites.
chlorodeoxyadenosine definition: adenosine deaminase-resistant congener of deoxyadenosine with selective toxicity towards lymphocytes and monocytes; used as an immunosuppressive in treating certain leukemias, lymphomas, and autoimmune disorders.
cladribine definition: A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41184&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41184&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1336" NCI Thesaurus)
Cladribine definition: A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
 
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