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3-methylbutanal reductase activity definition: Catalysis of the reaction: isoamyl alcohol (3-methylbutanol) + NADP+ = isovaleraldehyde (3-methylbutanal) + NADPH + H+. [EC:1.1.1.265]
 
Examples
 

Decreased concentrations after 18 h of incubation were found for acetaldehyde, 3-methylbutanal, butyl acetate, acetonitrile, acrolein, methacrolein, 2-methylpropanal, 2-butanone, 2-methoxy-2-methylpropane, 2-ethoxy-2-methylpropane, and hexanal.

Wojciech Filipiak et al.

Cancer Cell International 8 (7), 24 Nov 2008

Reagents and standards 2-Butanone, acrolein, methacrolein, 2-ethylacrolein, 2-methylpropanal, 3-methylbutanal, 2-methylbutanal, 2-methyl-2-butenal, hexanal, n-butyl acetate, methyl tert-butyl ether, ethyl tert-butyl ether, 2,4-dimethylpentane, 2,3,4-trimethylpentane, decane and tetrahydrofuran were each purchased from Sigma-Aldrich (Sigma-Aldrich, Steinheim, Germany).

Wojciech Filipiak et al.

Cancer Cell International 8 (7), 24 Nov 2008

Compound t R [min] CAS 1 Methyl alcohol 8,778 67-56-1 2 Dimethyl ether 10,323 115-10-6 3 Acetaldehyde 11,936 75-07-0 4 Methanethiol 13,130 74-93-1 5 Isobutane 15,785 75-28-5 6 2-Methyl-1-propene 16,118 115-11-7 7 Ethyl alcohol 16,517 64-17-5 8 Acetonitrile (a) 17,423 75-05-8 9 2-Butene (Z or E isomer) 17,009 107-01-7 10 Butane 17,186 106-97-8 11 2-Butene (E or Z isomer) 17,360 115-11-7 12 2-Propenal (b) 19,310 107-02-8 13 Furan 19,741 110-00-9 14 Propanal 20,170 123-38-6 15 Acetone 20,469 67-64-1 16 Isopropyl Alcohol 21,720 67-63-0 17 2-Methylbutane 23,229 78-78-4 18 Ethyl ether 23,503 60-29-7 19 1-Propanol 23,696 71-23-8 20 Pentane 24,224 109-66-0 21 Methacrolein (c) 25,375 78-85-3 22 2-Methylpropanal (d) 25,917 78-84-2 23 Methyl vinyl ketone 26,795 78-94-4 24 Trichloromethane 27,561 67-66-3 25 Tetrahydrofuran 27,920 109-99-9 26 2-Butanone (e) 28,124 78-93-3 27 Ethyl acetate 29,829 141-78-6 28 2-Methoxy-2-methylpropane (f) 30,377 1634-04-4 29 2-Methyl-1-pentene 31,692 763-29-1 30 Benzene 32,418 71-43-2 31 Hexane 33,003 110-54-3 32 2-Ethylacrolein 34,049 922-63-4 33 3-Methylbutanal (g) 34,587 590-86-3 34 2-Ethoxy-2-methylpropane (h) 35,346 637-92-3 35 2-Pentanone 35,868 107-87-9 36 Methyl methacrylate 36,121 80-62-6 37 2-Methyl-2-butenal 37,277 1115-11-3 38 3-Methylhexane 38,434 589-34-4 39 Cyclopentanone 38,750 120-92-3 40 Toluene 39,466 108-88-3 41 Furfural 40,044 98-01-1 42 Methyl isobutyl ketone 40,262 108-10-1 43 Hexanal (i) 42,001 66-25-1 44 Butyl acetate (j) 42,624 123-86-4 45 2,3,4-Trimethylpentane 42,949 565-75-3 46 2,3,3-Trimethylpentane (k) 43,202 560-21-4 47 4-Methylheptane 43,385 589-53-7 48 3-Ethylhexane 43,580 619-99-8 49 Octane 44,465 111-65-9 50 p-Xylene 44,721 106-42-3 51 Styrene 45,195 100-42-5 52 p-Xylene 45,363 106-42-3 53 3-Methyl-2(5H)-furanone 45,779 22122-36-7 54 2,3,5-Trimethylhexane (l) 46,456 1069-53-0 55 2,4-Dimethylheptane (m) 46,647 2213-23-2 56 Benzaldehyde 46,799 100-52-7 57 4-Methyloctane (n) 47,697 2216-34-4 58 Octanal 50,921 124-13-0 59 Limonene 52,217 138-86-3 60 Decane 52,572 124-18-5 Listed are substances observed in the headspace of medium as well as in the headspace of CALU-1 cancer cells.

Wojciech Filipiak et al.

Cancer Cell International 8 (7), 24 Nov 2008

A Concentration [ppb v ] after 4 hours of incubation mean ppb Medium mean ppb Cells ppb Cells/ppb Medium Compound CAS R 2 LOD [ppb v ] Medium Cells methacrolein 78-85-3 0,999 0,466 5,66 9,38 3,93 0,63 0,34 0,84 0,34 0,34 4,898 0,469 0,10 2-methylpropanal 78-84-2 0,998 0,143 19,80 12,98 39,53 9,12 1,21 below LOD 3,35 2,03 20,357 1,649 0,08 methyl tert-butyl ether 1634-04-4 0,999 0,293 1,68 3,43 3,56 1,60 0,67 0,94 1,30 1,11 2,567 1,004 0,39 3-methylbutanal 590-86-3 0,994 0,234 142,29 184,19 218,74 73,14 0,08 2,44 3,02 2,13 154,588 1,916 0,01 n-butyl acetate 123-86-4 0,999 0,134 60,47 105,13 66,58 58,08 2,01 14,70 11,27 13,08 72,566 10,267 0,14 B Compound CAS R 2 LOD [ppb v ] Concentration [ppb v ] after 18 hours of incubation mean ppb Medium mean ppb Cells ppb Cells/ppb Medium Medium Cells acetaldehyde 75-07-0 0,993 1,517 257,527 335,818 315,063 below LOD 116,472 81,692 302,803 66,054 0,22 acetonitrile 75-05-8 0,998 0,147 11,344 7,540 5,764 4,183 3,633 4,100 8,216 3,972 0,48 acrolein 107-02-8 0,998 0,718 5,703 3,462 4,079 2,185 2,071 3,238 4,415 2,498 0,57 methacrolein 78-85-3 0,999 0,466 5,933 4,975 4,723 0,811 0,344 0,702 5,210 0,619 0,12 2-methylpropanal 78-84-2 0,998 0,143 30,915 11,773 21,277 0,532 3,573 0,083 21,322 1,396 0,07 2-butanone 78-93-3 0,999 0,149 3,523 5,206 3,084 1,114 2,812 1,669 3,938 1,865 0,47 methyl tert-butyl ether 1634-04-4 0,999 0,293 2,126 4,202 2,089 0,753 1,654 1,023 2,806 1,143 0,41 3-methylbutanal 590-86-3 0,994 0,234 157,462 206,895 78,027 2,226 2,215 1,529 147,461 1,990 0,01 ethyl tert-butyl ether 637-92-3 0,999 0,215 6,168 11,281 5,121 2,060 4,805 2,229 7,523 3,032 0,40 2-methyl-2-butenal 1115-11-3 0,985 0,430 1,839 1,024 1,163 below LOD below LOD below LOD 1,342 0,000 0,00 hexanal 66-25-1 0,981 0,540 2,043 2,805 1,980 0,791 1,016 0,711 2,276 0,839 0,37 n-butyl acetate 123-86-4 0,999 0,134 43,949 31,381 26,348 11,084 3,032 3,324 33,892 5,813 0,17 The concentration of these VOCs is decreased in headspace of CALU-1 cells in comparison with medium only.

Wojciech Filipiak et al.

Cancer Cell International 8 (7), 24 Nov 2008

Decreased concentrations from cancer cells after 4 h were found for the compounds methacrolein (0,10), 2-methylpropanal (0,08), 2-methoxy-2-methylpropane (0,39), 3-methylbutanal (0,01), 2-methyl-2-butenal (0) and n-butyl acetate (0,14) (Figure 3 and Figure 4A ).

Wojciech Filipiak et al.

Cancer Cell International 8 (7), 24 Nov 2008

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