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Tel: +47 22854840; Fax: +47 22854443; Email: [email protected] 2004 1 12 2004 32 21 6260 6267 8 11 2004 9 11 2004 Copyright © 2004 Oxford University Press 2004 The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively.

Pål Ø. Falnes

Nucleic Acids Research 32 (21), 2004

Third, the AlkB protein was recently found to be an oxidative demethylase which directly reverses 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions ( 6 , 7 ).

Pål Ø. Falnes

Nucleic Acids Research 32 (21), 2004

Tel: +47 22854840; Fax: +47 22854443; Email: [email protected] 2004 30 6 2004 32 11 3456 3461 30 4 2004 28 5 2004 28 5 2004 Copyright © 2004 Oxford University Press 2004 Methylating agents introduce cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) residues into nucleic acids, and it was recently demonstrated that the Escherichia coli AlkB protein and two human homologues, hABH2 and hABH3, can remove these lesions from DNA by oxidative demethylation.

Pål Ø. Falnes et al.

Nucleic Acids Research 32 (11), 2004

It was recently discovered that AlkB is an oxidative demethylase which directly reverses 1-methyladenine (1-meA) and 3-methylcytosine lesions [reviewed in ( 3 )].

Pål Ø. Falnes et al.

Nucleic Acids Research 32 (11), 2004

Tel: +1 773 7025061; Fax: +1 773 7020805; Email: [email protected] a The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors 2004 5 3 2004 32 4 1548 1554 6 11 2003 8 2 2004 10 2 2004 Copyright © 2004 Oxford University Press 2004 The Escherichia coli AlkB protein was recently found to repair cytotoxic DNA lesions 1-methyladenine and 3-methylcytosine by using a novel iron-catalyzed oxidative demethylation mechanism.

Yukiko Mishina et al.

Nucleic Acids Research 32 (4), 2004

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