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Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum

John E Oatis et al.

Chemistry Central Journal , 24 Jun 2008

Roughing up Smoothened: chemical modulators of Hedgehog signaling: ... signaling, such as cyclopamine, have been known for ...

Randall W King

Journal of Biology , 2002

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling: ... specific inhibitor cyclopamine and the ErbB signalling ...

Greg Shaw et al.

Cancer Cell International , 18 Mar 2008

Activation of the hedgehog pathway in advanced prostate cancer: ... smoothened antagonist, cyclopamine, suppresses hedgehog ...

Tao Sheng et al.

Molecular Cancer , 13 Oct 2004

Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells: ... on cell survival, cyclopamine had a potent killing ...

Mohamed Ali-Seyed et al.

BMC Cancer , 07 Mar 2006

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: ... Hh-signaling antagonist cyclopamine, and a novel ...

Maria Frank-Kamenetsky et al.

Journal of Biology , 2002

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion: ... with high affinity in a cyclopamine-sensitive manner. ...

Maarten F Bijlsma et al.

PLoS Biology , 01 Aug 2006

The Zebrafish Mutants dre, uki, and lep Encode Negative Regulators of the Hedgehog Signaling Pathway: ... Hh activity by cyclopamine rescues uki and lep ...

Marco J Koudijs et al.

PLoS Genetics , 01 Aug 2005