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4 words
analysis of variance /ANOVA/ Varianzanalyse
Analysis of Variance definition: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Analysis of Variance definition: A statistical technique which helps in making inference whether three or more samples might come from populations having the same mean; specifically, whether the differences among the samples might be caused by chance variation.
NOVA2 Gene definition: This gene is involved in neuronal development and RNA splicing events.
Neuro-Oncological Ventral Antigen 2 definition: Expressed in brain by human NOVA2 Gene, RNA-binding NOVA2 protein is recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI)
NOVA2 wt Allele definition: Human NOVA2 wild-type allele is located in the vicinity of 19q13.3 and is approximately 34 kb in length. This allele, which encodes RNA-binding protein Nova-2, plays a role in the regulation of RNA splicing or metabolism in a specific population of developing neurons.
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