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Aryl Hydrocarbon Receptor Nuclear Translocator definition: Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
aryl hydrocarbon receptor nuclear translocator activity definition: OBSOLETE (was not defined before being made obsolete). [GOC:mah]
ARNT2 Gene definition: This gene plays a regulatory role in transcription in response to developmental and environmental stimuli.
ARNT Gene definition: This gene is involved in xenobiotic metabolism and receptor-ligand mediated interactions.
Aryl Hydrocarbon Receptor Nuclear Translocator 2 definition: Aryl Hydrocarbon Receptor Nuclear Translocator 2, encoded by the ARNT2 gene, is a member of a novel transcription factor family consisting of a conserved basic helix-loop-helix (bHLH) structural motif contiguous with a PAS domain. (From LocusLink)
Aryl Hydrocarbon Receptor Nuclear Translocator definition: Aryl Hydrocarbon Receptor Nuclear Translocator, encoded by the ARNT gene, heterodimers with HIF1A or EPAS1/HIF2A and functions as a transcriptional regulator of the adaptive response to hypoxia. Efficient DNA binding requires dimerization with another bHLH protein. This nuclear protein is also required for activity of the Ah (dioxin) receptor and for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. (From Swiss-Prot and LocusLink)
ARNT wt Allele definition: Human ARNT wild-type allele is located in the vicinity of 1q21 and is approximately 67 kb in length. This allele, which encodes aryl hydrocarbon receptor nuclear translocator protein, plays a role in the modulation of the transcriptional response to halogenated aromatic hydrocarbons. This gene and the ETV6 gene are involved in a translocation t(1;12)(q21;p13) that is associated with acute myeloblastic leukemia.
ARNT2 wt Allele definition: Human ARNT2 wild-type allele is located in the vicinity of 15q24 and is approximately 194 kb in length. This allele, which encodes aryl hydrocarbon receptor nuclear translocator 2 protein, plays a role in the regulation of the transcriptional responses to both xenobiotic chemicals and environmental stimuli.
ARNTL Transcription Factors definition: Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.
 
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