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Arylamine N-Acetyltransferase definition: An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.
Arylamine N-Acetyltransferase 2 definition: Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA. [EC created 1961] (from IUBMB)
Arylamine N-Acetyltransferase 2 definition: Arylamine N-acetyltransferase, the encoded product of the NAT2 gene, is the polymorphic enzyme responsible for the "acetylator phenotype"; rapid or slow acetylation of therapeutic and carcinogenic agents is due to variation at the NAT2 locus. The slow phenotype results from decreased or absent arylamine N-acetyltransferase in the liver. A relationship appears to exist between acetylator phenotype and DNA damage by chemicals that undergo N-acetylation. Acetylation polymorphism may be a factor in susceptibility to toxicity and perhaps carcinogenicity of target chemicals. (from OMIM 243400 and NCI)
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