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Virus Assembly definition: The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
virus assembly definition: coming together of the constituent parts of a virus particle; process can vary from autoassembly of protein subunits around the viral nucleic acid to assembly of complex viruses at cell membranes.
virion assembly definition: A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. [ISBN:0121585336]
6 examples

Intracellular HIV-1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers: ... NC plays key roles in virus structure and replication via its nucleic acid binding and chaperoning properties. In fact, NC controls proviral DNA synthesis by reverse transcriptase (RT), gRNA dimerization and packaging, and virion assembly. Results We ...

Boyan Grigorov et al.

Retrovirology , 03 Aug 2007

A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis: ... recombinant virus was constructed in which the expression of the vaccinia virus I7L gene is under the control of the tetracycline operator/repressor system. In the absence of I7L expression, processing of the major VV core proteins is inhibited and electron microscopy reveals defects in virion morphogenesis subsequent to the formation of immature virion particles but prior to core condensation. Plasmid-borne I7L is capable of rescuing the growth of this virus and rescue is optimal when the I7L gene is expressed using the authentic I7L promoter. Taken together, these data suggest that correct temporal expression of the VV I7L cysteine proteinase is required for core protein maturation, virion assembly and production of ...

Chelsea M Byrd et al.

Virology Journal , 08 Feb 2005

Quantitative analysis of Nipah virus proteins released as virus-like particles reveals central role for the matrix protein: Background Nipah virus (NiV) is an emerging paramyxovirus distinguished by its ability to cause fatal disease in both animal and human hosts. Together with Hendra virus (HeV), they comprise the genus Henipavirus in the Paramyxoviridae family. NiV and HeV are also restricted to Biosafety Level-4 containment and this has hampered progress towards examining details of their replication and morphogenesis. Here, we have established recombinant expression systems to study NiV particle assembly and budding through the ...

Jared R Patch et al.

Virology Journal , 04 Jan 2007

Characterisation of cauliflower mosaic virus DNA forms isolated from infected turnip leaves.: ... of cauliflower mosaic virus (CaMV) DNA were detected in nucleic acid preparations from CaMV-infected turnip leaves. As well as supercoiled and open-circular molecules, various linear DNA structures were identified. The relative amounts of these DNA forms varied in plants infected with different CaMV isolates. Restriction enzyme mapping and one- and two-dimensional gel electrophoresis revealed the presence of linear molecules apparently formed by breaks in the second strand at each of the three discontinuities. Two major linear DNA forms are double-stranded over part of their length and appear to have single-stranded extensions of the -strand of variable length. Since these DNA forms are not produced during extraction and probably exist as unencapsidated or partially encapsidated molecules, they may represent intermediates either in DNA replication or in virion assembly. Images

R Hull et al.

Nucleic Acids Research , 25 Mar 1983

Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma: ... species such as Sindbis virus and Semliki Forest virus are important vectors for gene therapy, vaccination and cancer research, and important models for virion assembly and structural ...

Andrew E Firth et al.

Virology Journal , 26 Sep 2008

Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production: ... in the process of virion assembly at the plasma membrane, ...

Margaret Q Wang et al.

Journal of Biology , 2004

Viral RNA annealing activities of the nucleocapsid protein of Moloney murine leukemia virus are zinc independent.: ... both dimerization of viral RNA and annealing of the replication primer tRNA onto viral RNA, two reactions necessary for the production of infectious virions. In this study the role of the zinc finger of Moloney murine leukemia virus (MoMuLV) NCp10 in RNA binding and annealing activities was investigated through modification or replacement of residues involved in zinc coordination. These alterations did not affect the ability of NCp10 to bind RNA and promote RNA annealing in vitro, despite a complete loss of zinc affinity. However mutation of two conserved lysine residues adjacent to the finger motif reduced both RNA binding and annealing activities of NCp10. These findings suggest that the complexed NC zinc finger is not directly involved in RNA-protein interactions but more probably in a zinc dependent conformation of NC protein modulating viral protein-protein interactions, essential to the process of viral RNA selection and virion assembly. Then the NC zinc ...

A C Prats et al.

Nucleic Acids Research , 11 Jul 1991

Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism.: ... related events during virion assembly. We studied the ...

R Marquet et al.

Nucleic Acids Research , 11 May 1991

Controlling bacteriophage phi29 DNA-packaging motor by addition or discharge of a peptide at N-terminus of connector protein that interacts with pRNA: ... the pRNA binding and virion assembly activity were greatly ...

Jianhe Sun et al.

Nucleic Acids Research , 01 Nov 2006

RNA-binding properties of influenza A virus matrix protein M1.: ... (M1) of influenza A virus, which has a critical role in viral assembly and can inhibit the ...

L Wakefield et al.

Nucleic Acids Research , 11 Nov 1989

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