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Protein Phosphatase 2 Regulatory Subunit B Gamma definition: Ubiquitously expressed as 3 isoforms by human PPP2R5C Gene (PP2A Subunit B Family), Protein Phosphatase 2 Regulatory Subunit B Gamma is a regulatory subunit of PP2A. Nuclear Gamma-3 is serine phosphorylated, while nuclear Gamma-1 is not. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
PPP2R5C Gene definition: This gene plays a role in the negative control of cell growth and division.
 
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