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CDH1 Gene definition: This gene plays a role in cell-cell adhesion and loss of function contributes to the progression of many carcinomas.
Reagents, Molecular Assay, Gene Anomaly, Mutation, CDH1 definition: Molecular assay reagents intended to identify mutations in the cadherin 1, type 1, E-cadherin (epithelial) (CDH1) gene, located at chromosome 16q22.1, which encodes for a calcium-dependent cell-cell adhesion glycoprotein. Mutations at this locus have been identified in patients with early-onset gastric, breast, colorectal, thyroid, and ovarian cancer.
 
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