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Electrophoretic mobility shift analysis showed specific binding of NCU-G1 to an oligonucleotide representing the footprint 1 element of the human cellular retinol-binding protein 1 gene promoter.

Knut R Steffensen et al.

BMC Molecular Biology 8 (7), 16 Nov 2007

Retinol (ROH) is taken up from circulating retinol-binding protein (RBP) or released from intracellular storage of retinylester and transferred to cellular retinol-binding protein type 1 (CRBP1) which regulates its metabolism.

Knut R Steffensen et al.

BMC Molecular Biology 8 (7), 16 Nov 2007

List of abbreviations AF2 activation function domain 2 AP1 Activating protein 1 Bp1 binding protein 1 Bp2 binding protein 2 cAMP adenosine 3',5'-cyclic monophosphate CAT chloramphenicol acetyl-transferase CRBP1 cellular retinol-binding protein 1

Knut R Steffensen et al.

BMC Molecular Biology 8 (7), 16 Nov 2007

Additionally, many glial or related proteins were found to be differentially regulated in PD (GFAP, GMFB, galectin-1, sorcin), as well as proteins belonging to metabolic pathways sparsely described in PD, such as adenosyl homocysteinase (methylation), aldehyde dehydrogenase 1 and cellular retinol-binding protein 1 (aldehyde metabolism).

Cornelius J Werner et al.

Proteome Science 6 (7), 14 Feb 2008

Aldehyde dehydrogenase A1 (ADH1A1) and cellular retinol-binding protein 1 (CRBP1), both involved in aldehyde metabolism, were also differentially expressed in an increased manner as compared to controls.

Cornelius J Werner et al.

Proteome Science 6 (7), 14 Feb 2008

 
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