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3 words
chronic granulocytic leukemia Chronische myeloische Leukämie
 
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Blast Crisis definition: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.
blast phase definition: The phase of chronic myelogenous leukemia in which the number of immature, abnormal white blood cells in the bone marrow and blood is extremely high.
Blast Phase Chronic Myelogenous Leukemia definition: An advanced phase of chronic myelogenous leukemia. It is characterized by: 1. the presence of blasts in the peripheral blood or bone marrow that are at least 20% of the peripheral blood white cells or of the nucleated cells in the bone marrow respectively, or 2. an extramedullary proliferation of blasts, and/or 3. when there are large aggregates and clusters of blasts in the bone marrow biopsy specimen (adapted from WHO, 2001).
Leukemia, Myeloid, Accelerated Phase definition: The phase of chronic myeloid leukemia following the chronic phase (LEUKEMIA, MYELOID, CHRONIC-PHASE), where there are increased systemic symptoms, worsening cytopenias, and refractory LEUKOCYTOSIS.
accelerated phase chronic myelogenous leukemia definition: (ak-SEH-leh-ray-ted FAYZ KRAH-nik MY-eh-LAH-jeh-nus loo-KEE-mee-uh) A phase of chronic myelogenous leukemia in which the disease is progressing. In this phase, 6% to 30% of the cells in the blood and bone marrow are blast cells (immature blood cells).
Accelerated Phase Chronic Myelogenous Leukemia definition: A phase of chronic myelogenous leukemia characterized by one or more of the following: 1) Myeloblasts accounting for 10-19% of the peripheral blood white cells or of the nucleated cells in the bone marrow, 2) peripheral blood basophils at least 20%, 3) persistent thrombocytopenia that is unrelated to therapy, 4) persistent thrombocytosis despite adequate therapy, 5) increasing white blood cell count and increasing spleen size unresponsive to therapy, and/or evidence of clonal evolution. (WHO, 2001)
chronic myelogenous leukemia definition: chronic leukemia in which myeloid progenitor cells predominate; the hallmark of CML, the Philadelphia chromosome, is a reciprocal translocation between chromosomes 9 and 22 which activates the proto- oncogene c-abl.
chronic myeloid leukemia definition: A slowly progressing disease in which too many white blood cells are made in the bone marrow.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive definition: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Chronic Myelogenous Leukemia definition: The most common chronic myeloproliferative disorder characterized by neutrophilic leukocytosis. It is associated with the Philadelphia (Ph) chromosome and/or the BCR/ABL fusion gene. Most patients are middle-aged or elderly. Common findings at presentation include fatigue, weight loss, anemia, night sweats, and splenomegaly. The disease is bi- or triphasic; an initial indolent chronic phase is followed by an accelerated or blast phase. Allogeneic bone marrow transplantation is currently the only curative therapy (adapted from WHO 2001).
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