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Cofactor Required for Sp1 Transcriptional Activation Subunit 4 definition: Encoded by human CRSP4 Gene, Cofactor Required for Sp1 Transcriptional Activation Subunit 4 is 100-kD protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)
MED24 Gene definition: This gene plays a role in the transcriptional activation of Sp1.
MED24 wt Allele definition: Human MED24 wild-type allele is located in the vicinity of 17q21.1 and is approximately 35 kb in length. This allele, which encodes thyroid hormone receptor-associated protein complex 100 kDa component protein, may be involved in transcriptional initiation.
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