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Chemokine CCL8 definition: A monocyte chemoattractant protein that attracts MONOCYTES; LYMPHOCYTES; BASOPHILS; and EOSINOPHILS. Chemokine CCL8 has specificity for CCR3 RECEPTORS and CCR5 RECEPTORS.
Small Inducible Cytokine A8 definition: This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. (from LocusLink)
Small Inducible Cytokine A8 definition: Chemokines, a family of small cytokines, attract leukocytes and possess various immunomodulating functions. CC chemokines influence mononuclear cell types. Human Macrophage Chemoattractant Protein-2 is a chemotactic factor for monocytes, lymphocytes, basophils and eosinophils. This monomer or homodimer can bind heparin. Its expression is induced by interferon gamma, mitogens, and IL-1. (from OMIM 602283, Swiss-Prot P80075, and NCI)
CCL8 Gene definition: This gene is involved in the modulation of immune functions.
CCR8 Gene definition: This gene plays a role in the regulation of chemotaxis and apoptosis.
IL8 Gene definition: This gene plays a role in the mediation of inflammatory responses and in angiogenesis.
CCR8 wt Allele definition: Human CCR8 wild-type allele is located within 3p22 and is approximately 5 kb in length. This allele, which encodes C-C chemokine receptor type 8 protein, plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis.
CCL8 wt Allele definition: Human CCCL8 wild-type allele is located within 17q11.2 and is approximately 2 kb in length. This allele, which encodes small inducible cytokine A8 protein, plays a role in the chemotaxis of monocytes, lymphocytes, basophils and eosinophils. The recruitment of leukocytes may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
 
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