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DEAD/H Box Protein 1 definition: Encoded by human DDX1 Gene and highly expressed in neuroectodermal tissues, 740-amino acid 82.4-kD DEAD/H Box Protein 1 has unknown function, contains a SPRY domain, and belongs to the DEAD/H box ATP-dependent RNA helicase family. DEAD box proteins, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
DDX1 Gene definition: This gene plays a role in the regulation of several processes involving the alteration of RNA secondary structure.
DDX1 wt Allele definition: Human DDX1 wild-type allele is located in the vicinity of 18q21.3 and is approximately 40 kb in length. This allele, which encodes ATP-dependent RNA helicase DDX1 protein, is involved in the regulation of processes that are dependent on the alteration of RNA secondary structure.
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