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DEAD/H Box Protein 1 definition: Encoded by human DDX1 Gene and highly expressed in neuroectodermal tissues, 740-amino acid 82.4-kD DEAD/H Box Protein 1 has unknown function, contains a SPRY domain, and belongs to the DEAD/H box ATP-dependent RNA helicase family. DEAD box proteins, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
DDX1 Gene definition: This gene plays a role in the regulation of several processes involving the alteration of RNA secondary structure.
DDX1 wt Allele definition: Human DDX1 wild-type allele is located in the vicinity of 18q21.3 and is approximately 40 kb in length. This allele, which encodes ATP-dependent RNA helicase DDX1 protein, is involved in the regulation of processes that are dependent on the alteration of RNA secondary structure.
 
Examples
 

Recent results showed that certain DEAD box protein RNA helicases, DDX3 and DDX1, play an important role in the HIV infection cycle by facilitating the export of long, singly spliced or unspliced HIV RNAs from the nucleus via the CRM1-Rev pathway.

Vyjayanthi Krishnan et al.

Retrovirology 1 (7), 08 Dez 2004

Close examination of an extensive microarray expression profiling dataset obtained from cells latently infected with HIV induced to undergo lytic viral replication indicated that additional DEAD box proteins, beyond DDX3 and DDX1, exhibit differential expression during lytic HIV replication, and in latently infected cells prior to induction into active replication.

Vyjayanthi Krishnan et al.

Retrovirology 1 (7), 08 Dez 2004

Recent work, reviewed in reference [ 6 ], from the Jeang [ 7 ] and Pomerantz [ 8 ] laboratories implicate the DDX3 and DDX1 DEAD box proteins as additional critical co-factors for the Rev-mediated export of the long HIV singly spliced and unspliced mRNAs.

Vyjayanthi Krishnan et al.

Retrovirology 1 (7), 08 Dez 2004

In a directed analysis of a large data set, which describes global changes in cellular gene patterns before and after a latently infected cell line was induced into active viral replication [ 9 ], we found that genes encoding many DEAD box proteins, and other RNA and DNA binding and modification proteins, in addition to DDX3 and DDX1, showed differential regulation, suggesting that HIV replication may be associated with generalized changes in the expression of many DEAD box proteins and other RNA binding proteins.

Vyjayanthi Krishnan et al.

Retrovirology 1 (7), 08 Dez 2004

Fang et al. [ 8 ] identified DDX1 in a two hybrid screen as a Rev- and RRE-binding protein that enhanced HIV replication, improved the expression of RRE-containing RNA, and modified the subcellular distribution of Rev from a predominantly nuclear to a predominantly cytoplasmic distribution.

Vyjayanthi Krishnan et al.

Retrovirology 1 (7), 08 Dez 2004

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