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Dimethyl Sulfoxide definition: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethylsulfoxide definition: highly polar organic liquid, that is used widely as a chemical solvent; because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals; it is also used to protect tissue during cryopreservation; dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide definition: A colorless liquid that readily dissolves many chemicals and penetrates animal and plant tissues. It is used in human medicine, veterinary medicine, and pharmaceuticals.
dimethyl sulfoxide definition: A polar organic solvent. DMSO is a free radical scavenger that has been used to treat extravasation damage caused by anthracycline-based chemotherapy. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39222&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39222&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C437" NCI Thesaurus)
Dimethyl Sulfoxide definition: A highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger. It shows a range of pharmacological activity including analgesia and anti-inflammation. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect cells and tissue during cryopreservation and has been used to treat extravasation damage caused by anthracycline-based chemotherapy.
dimethyl sulfoxide metabolic process definition: The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing. [http://cancerweb.ncl.ac.uk/]
 
Examples
 

The interaction between cis- and trans- RuCl 2 (DMSO) 4 and human serum albumin have been investigated through UV-Vis, circular dichroism, fluorescence spectroscopy and inductively couplet plasma atomic emission spectroscopy (ICP(AES)) method Albumin can specifically bind 1 mole of cis-isomer and 2 moles of the trans-isomer RuCl 2 (DMSO) 4 complex.

Lilianna Trynda-Lemiesz et al.

Metal-Based Drugs 7 (6), 2000

The interaction of RuCl 2 (DMSO) 4 with HSA causes: a conformational change with the loss of helical stability of protein; the strong quenching of the Trp 214 fluorescence indicating that the conformational change of the hydrophobic binding pocked in subdomain IIA takes place; a local perturbation of the warfarin binding site and induce some conformational changes at neighbour domains, a changing of the binding abilities towards heme.

Lilianna Trynda-Lemiesz et al.

Metal-Based Drugs 7 (6), 2000

We demonstrate that dimethyl sulfoxide (DMSO) facilitated a better DNA uptake in four different cell lines (HL60, TR146, Cos-7 and L132).

H Melkonyan et al.

Nucleic Acids Research 24 (21), 01 Nov 1996

The cells were electroporated with a beta-Gal expression plasmid in a medium containing DMSO (1.25%) during, and for 24 h after the pulse.

H Melkonyan et al.

Nucleic Acids Research 24 (21), 01 Nov 1996

We also observed that the vehicle, dimethyl sulfoxide (DMSO), caused a significant reduction in the ability of the splenic leukocytes to express surface immunoglobin M (SIgM) at this time.

Ruth H Milston et al.

Environmental Health Perspectives 111 (13), 01 Oct 2003

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