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Topoisomerase II Alpha definition: Encoded by human TOP2A Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa) control DNA topology. TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Topoisomerase II Alpha definition: Involved in chromosome condensation and segregation, topoisomerase II alpha is a homodimer that controls DNA topology by transient ATP-dependent double-strand breakage and rejoining. Topoisomerase II alpha is also associated with the Pol II holoenzyme and required for chromatin-dependent co-activation and productive RNA synthesis. (from OMIM 126430 and NCI)
 
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