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Receptors, Aryl Hydrocarbon definition: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Aryl Hydrocarbon Receptor definition: The aryl hydrocarbon receptor (AhR) is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. Many foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are ligands of AhR. Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AhR.
Aryl Hydrocarbon Receptor Nuclear Translocator definition: Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
ARNT Gene definition: This gene is involved in xenobiotic metabolism and receptor-ligand mediated interactions.
Aryl Hydrocarbon Receptor Nuclear Translocator definition: Aryl Hydrocarbon Receptor Nuclear Translocator, encoded by the ARNT gene, heterodimers with HIF1A or EPAS1/HIF2A and functions as a transcriptional regulator of the adaptive response to hypoxia. Efficient DNA binding requires dimerization with another bHLH protein. This nuclear protein is also required for activity of the Ah (dioxin) receptor and for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. (From Swiss-Prot and LocusLink)
ARNT wt Allele definition: Human ARNT wild-type allele is located in the vicinity of 1q21 and is approximately 67 kb in length. This allele, which encodes aryl hydrocarbon receptor nuclear translocator protein, plays a role in the modulation of the transcriptional response to halogenated aromatic hydrocarbons. This gene and the ETV6 gene are involved in a translocation t(1;12)(q21;p13) that is associated with acute myeloblastic leukemia.
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