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Valproic Acid definition: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
valproic acid definition: A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=350047&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=350047&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29536" NCI Thesaurus)
Divalproex definition: A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.
Valproic Acid definition: A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
 
Examples
 

Case Presentation A 36 year old man with severe anaemia was prescribed divalproex sodium 250 mg daily for mood swings.

Maneesh Gupta

Clinical practice and epidemiology in mental health : CP & EMH 3 (7), 10 Jul 2007

Divalproex sodium may result in severe side effects in clients with severe anaemia.

Maneesh Gupta

Clinical practice and epidemiology in mental health : CP & EMH 3 (7), 10 Jul 2007

This case report discusses the use of divalproex sodium in a client with severe anaemia.

Maneesh Gupta

Clinical practice and epidemiology in mental health : CP & EMH 3 (7), 10 Jul 2007

After some discussion he agreed to start divalproex sodium at 250 mg daily with the aim of gradually increasing the dose, so that his mood swings might be tackled and perhaps help him to reduce self harm.

Maneesh Gupta

Clinical practice and epidemiology in mental health : CP & EMH 3 (7), 10 Jul 2007

In consultation with the mental health team he stopped divalproex sodium.

Maneesh Gupta

Clinical practice and epidemiology in mental health : CP & EMH 3 (7), 10 Jul 2007

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