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Retinoblastoma-Like 2 definition: Expressed only in G0 by human RBL2 Gene (RB Family), 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI)
 
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Thyroid hormone – triiodothyronine – has contrary effect on proliferation of human proximal tubules cell line (HK2) and renal cancer cell lines (Caki-2, Caki-1) – role of E2F4, E2F5 and p107, p130

Piotr Poplawski et al.

Thyroid Research , 13 Oct 2008

A p130 Cas tyrosine phosphorylated substrate domain decoy disrupts v-Crk signaling

Kathrin H Kirsch et al.

BMC Cell Biology , 15 Jul 2002

Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice

Qin Chen et al.

Molecular Vision , 25 Mar 2008

PP2A-Mediated Dephosphorylation of p107 Plays a Critical Role in Chondrocyte Cell Cycle Arrest by FGF: ... of the p107 and p130 members of the Rb ...

Victoria Kolupaeva et al.

PLoS ONE , 17 Oct 2008

Compensation by tumor suppressor genes during retinal development in mice and humans: ... proteins (Rb, p107 and p130) are expressed in a ...

Stacy L Donovan et al.

BMC Biology , 03 May 2006

Insights from mouse models into human retinoblastoma: ... p107 ( Rbl1 ) and p130 ( Rbl2 ). There is ...

David MacPherson

Cell Division , 19 May 2008

SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy: ... members (p107 and p130). Accumulation of ...

Olena Barbash et al.

Cell Division , 15 Jan 2007

Coordinated Regulation of Intestinal Functions in C. elegans by LIN-35/Rb and SLR-2: ... its paralogs p107 and p130. In addition to having ...

Natalia V. Kirienko et al.

PLoS Genetics , 01 Apr 2008

E2F/p107 and E2F/p130 complexes are regulated by C/EBPalpha in 3T3-L1 adipocytes.

N A Timchenko et al.

Nucleic Acids Research , 01 Sep 1999

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia: ... pocket proteins, retinoblastoma-like 1 (p107) and ...

Karl Simin et al.

PLoS Biology , 01 Feb 2004