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Enzyme Inhibitor Protein definition: Encoded by Enzyme Inhibitor Genes, Enzyme Inhibitor Proteins block or suppress the catalytic activity of enzymes. (NCI)
 
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Mutations in either the enzyme or the inhibitor protein often lead to a modulation of the binding affinity with no major alterations in the 3D structure of the complex.

Daniele Dell'Orco et al.

BMC Structural Biology 7 (7), 08 Jun 2007

Enzyme-substrate and enzyme-inhibitor constitute the tightest protein-protein complexes [ 1 ], i.e. characterized by very low binding free energies (ΔG°).

Daniele Dell'Orco et al.

BMC Structural Biology 7 (7), 08 Jun 2007

The ability to modulate the binding affinity in enzyme-proteic inhibitor interactions is of high interest, both for probing the molecular determinants involved in recognition and stabilization of the protein-protein complex, and for unravelling the molecular mechanisms that underlie the early onset of pathological conditions (see for instance Refs. [ 2 , 3 ]).

Daniele Dell'Orco et al.

BMC Structural Biology 7 (7), 08 Jun 2007

Naturally occurring or artificially induced mutations in either the enzyme or the inhibitor protein represent a convenient way to modulate the binding affinity without altering significantly the three dimensional (3D) structure of the proteins.

Daniele Dell'Orco et al.

BMC Structural Biology 7 (7), 08 Jun 2007

The cases reported in this study indeed represent an interesting extension of the approach to the important class of enzyme-inhibitor interactions and allowed us to probe the accuracy and the applicability of the method for general protein design purposes.

Daniele Dell'Orco et al.

BMC Structural Biology 7 (7), 08 Jun 2007

 
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