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Translation
 
fyFrisian enEnglish
1 word
fak branch
fak compartment
fak craft
fak department
fak division
fak domain
fak estate
fak farm
fak handicraft
fak land
13 further results >>
 
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fyFrisian afAfrikaans
1 word
fak afdeling
fak ambag
fak bedryf
fak beroep
fak boereplaas
fak plaas
fak vak
 
fyFrisian bmBambara
1 word
fak bara
 
fyFrisian brBreton
1 word
fak micher
 
fyFrisian caCatalan
1 word
fak departament
fak especialitat
fak hisenda
fak ofici
fak secció
 
fyFrisian daDanish
1 word
fak afdeling
fak bondegård
fak fag
fak gård
fak stilling
 
fyFrisian deGerman
1 word
fak Abteilung
fak Bauerngut
fak Bauernhof
fak Bereich
fak Beruf
fak Besitzung
fak Fach
fak Gewerbe
fak Gut
fak Handwerk
1 further results >>
 
fyFrisian eoEsperanto
1 word
fak bieno
fak fako
fak metio
 
fyFrisian esSpanish
1 word
fak casilla
fak departamento
fak especialidad
fak finca
fak hacienda
fak oficio
fak propriedad
fak rama
fak sección
 
fyFrisian fiFinnish
1 word
fak lokero
fak maatila
 
fyFrisian foFaroese
1 word
fak bóndagarður
fak deild
fak grein
fak handverk
fak rúm
fak yrki
 
fyFrisian frFrench
1 word
fak domaine
fak méquier
fak métier
fak spécialité
 
fyFrisian huHungarian
1 word
fak gazdaság
 
fyFrisian ioIdo
1 word
fak mestiero
fak specaleso
 
fyFrisian isIcelandic
1 word
fak
fak búgarður
fak stórbýli
 
fyFrisian itItalian
1 word
fak bene
fak fattoria
fak mestiere
 
fyFrisian laLatin
1 word
fak vicus
fak villa
 
fyFrisian msMalay
1 word
fak vak
 
fyFrisian nlDutch
1 word
fak afdeling
fak ambacht
fak beroep
fak bezitting
fak boerderij
fak branche
fak goed
fak handwerk
fak landgoed
fak tak
1 further results >>
 
fyFrisian noNorwegian
1 word
fak avdeling
fak gård
 
fyFrisian ptPortuguese
1 word
fak arte
fak bens de raiz
fak compartimento
fak domínio
fak especialidade
fak fazenda
fak granja
fak indústria
fak ofício
fak profissão
4 further results >>
 
fyFrisian ruRussian
1 word
fak ферма
 
fyFrisian svSwedish
1 word
fak bondgård
fak fack
fak gård
fak säteri
fak yrke
 
fyFrisian tlTagalog
1 word
fak búkid
fak kabukirán
 
fyFrisian trTurkish
1 word
fak
 
fyFrisian zuZulu
1 word
fak ilipulazi
fak ipulazi
 
Definition
 
enEnglish
focal adhesion kinase definition: nonEC; endogenous substrate for insulin receptor associated tyrosine kinase.
Focal Adhesion Kinase 1 definition: endogenous substrate for insulin receptor associated tyrosine kinase. (CSP98)
Focal Adhesion Kinase 1 definition: Focal adhesion kinase (PTK2) lacks significant homology with other kinases and concentrates in focal adhesions between cells growing in extracellular matrix constituents. PTK2 contains phosphotyrosine in growing cells, or after treatment with cholecystokinin, bombesin, vasopressin, or endothelin, but little in detached cells. Activation of PTK2 may be important in signal transduction pathways triggered by neural peptides or by cell interactions with the extracellular matrix. PTK2 is a major substrate for pp60v-src. A CRK-associated tyrosine kinase substrate, p130-CAS, is a PTK2-interacting protein. This interaction requires the proline-rich region of PTK2 and the SH3 domain of p130-CAS. The interaction may also be a key element in integrin-mediated signal transduction and may represent a direct molecular link between the SRC and CRK oncoproteins. FAK may be an endogenous substrate for insulin receptor associated tyrosine kinase. (from OMIM and NCI)
Focal Adhesion Kinase 1 definition: A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Focal Adhesion Kinase 2 definition: A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.
FAK definition: OBSOLETE (was not defined before being made obsolete). [GOC:jic]
FAK Family Tyrosine Kinase definition: Soluble cytoplasmic non-receptor FAK (Focal Adhesion Kinase) Family Tyrosine Kinases catalyze the phosphorylation of tyrosine residues in proteins with ATP or other nucleotides as phosphate donors. FAK is found in intracellular signaling focal adhesion complexes following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions.
PTK2 Gene definition: This gene plays a role in apoptosis, cell motility and proliferation.
PTK2 wt Allele definition: Human PTK2 wild-type allele is located within 8q24-qter and is approximately 343 kb in length. This allele, which encodes focal adhesion kinase 1 protein, plays a role in the transduction of adhesion-dependent signals and is involved in adhesion-dependent cell survival signaling. The PTK2 gene is overexpressed in a number of types of cancer such as breast, cervical, colorectal, ovarian, prostate, and thyroid cancers.
FAK Inhibitor PF-00562271 definition: An orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. FAK inhibitor PF-00562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. As FAK is a signal transducer for integrins, inhibition of FAK by this agent may prevent integrin-mediated activation of several downstream signals including ERK, JNK/MAPK and PI3K/Akt. FAK and PYK2, upregulated in many tumor cell types, are involved in tumor cell invasion, migration and proliferation.
 
frFrench
métier definition: Profession.
métier definition: Domaine d’activité d’une entreprise.
métier definition: S’emploie quelquefois par opposition au mot art.
métier definition: Habileté technique, expérience d’un art.
métier definition: Fait de faire habituellement quelque chose dans des vues intéressées, en faire une sorte de trafic.
métier definition: Mauvaise habitude.
métier definition: Mécanisme, dispositif qui sert à certaines fabrications, à certains ouvrages.
métier definition: Pour les productions de l'esprit, désigne un en-cours.
domaine definition: Propriété d’une assez vaste étendue et contenant des biens-fonds de diverse nature.
domaine definition: Ce qui appartient à l'État, au souverain.
9 further definitions >>
fyFrisian
ambacht definition: Métier.
fak definition: Métier.
fak definition: Domaine, spécialité.
fek definition: Domaine, spécialité.