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Mucin 1 definition: Expressed as alternative isoforms in some hematopoietic cells and most glandular and ductal epithelial cells by human MUC1 Gene, highly glycosylated Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. MUC1 may protect epithelial surfaces, play a role in adhesion, cell-cell interactions, signaling, and metastasis. MUC1 may interact directly or indirectly with the actin cytoskeleton. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. MUC1 can bind to GRB2. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.
 
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