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NF-Kappa B p49/p100 definition: NF-Kappa B p49/p100 is the precursor of the NFKB p52 subunit. NFKB2 belongs to the Rel/Dorsal family, contains seven ANK repeats, and binds to REL (p65) proteins to form NFKB, which is trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (from SWISS-PROT Q00653, OMIM 164012, and NCI)
NF-kappa B p100 Precursor Protein definition: NF-kappa B p100 precursor protein helps retain TRANSCRIPTION FACTOR RELB in the CYTOPLASM and its full-length form inhibits NF-kappa B signaling. It is processed by the PROTEASOME to produce NF-kappa B p52 subunit.
NF-kappa B p52 Subunit definition: A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p100 precursor protein and is important for maturation of B-LYMPHOCYTES and adaptive HUMORAL IMMUNITY.
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