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Histone H3 definition: Histone H3 is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI)
Histone H3 definition: Arginine rich histone. One of four histones assembled into a nucleosomal core octamer. Various posttranslationally modified forms and variants exist. Combines with histone H4 in a heterotetramer of composition (H3)2(H4)2; one tetramer is incorporated in the nucleosomal octamer.
tritium definition: radioactive mass three isotope of hydrogen.
Receptors, Histamine H3 definition: A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)
FGFR1 Gene definition: This gene plays a role in mitogenesis and differentiation.
DOT1L Gene definition: This gene is involved in epigenetic control of gene expression.
histone H3-K9 methylation definition: The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone. [GOC:ai]
histone H3-K4 methylation definition: The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone. [GOC:ai]
H3 histamine receptor binding definition: Interacting selectively with a H3 histamine receptor. [GOC:mah, GOC:nln]
Histamine H3 Antagonists definition: Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to correct SLEEP DISORDERS and MEMORY DISORDERS.
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