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HCT116 Cells definition: Human COLORECTAL CARCINOMA cell line.
 
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To address this we used HCT116 cells overexpressing either wild-type or a catalytically inactive dominant negative SIRT3 .

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences 4 (5), 05 Sep 2008

Biochemical analysis of HCT116 cells over expressing the deacetylation mutant, as compared to wild-type SIRT3 gene, demonstrated an overall oxidized intracellular environment, as monitored by increase in intracellular superoxide and oxidized glutathione levels.

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences 4 (5), 05 Sep 2008

S1) were constructed by transfecting pcDNA4, pCMV-SIRT3-wt, or pCMV-SIRT3 in HCT116 cells using FuGene 6 and selected with zeosin (supplemental Fig.

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences 4 (5), 05 Sep 2008

To ensure that this interaction was not an artifact of the COS-7 cell line, or the transient transfection conditions, HCT116 cells, which contain undetectable levels of endogenous SIRT3 by western analysis, were stably transfected with p-myc-hSIRT3-wt, and p-myc-hSIRT3-mt SIRT3 expression vectors (Fig S2).

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences 4 (5), 05 Sep 2008

As expected, similar results were seen in HCT116 and HCT116 cells genetically altered to express either the wild-type or deacetylation null SIRT3 genes (Fig.

Kristi Muldoon Jacobs et al.

International Journal of Biological Sciences 4 (5), 05 Sep 2008

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