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Translation
 
enEnglish deGerman
1 word
HCL Haarzellenleukämie
 
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enEnglish frFrench
1 word
HCL LEUCEMIE A TRICHOLEUCOCYTES
 
enEnglish ptPortuguese
1 word
HCL LEUCEMIA DE CELULAS CABELUDAS
 
Definition
 
enEnglish
Hydrochloric Acid definition: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
hydrochloric acid definition: aqueous solutions of hydrogen chloride; a highly corrosive strong mineral acid, used as a laboratory reagent and also secreted by the gastric parietal cells.
Leukemia, Hairy Cell definition: A neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of "hairy" or "flagellated" cells in the blood and bone marrow.
hairy cell leukemia definition: neoplastic disease of the lymphoreticular cells which is considered to be a rare type of chronic leukemia; it is characterized by an insidious onset, splenomegaly, anemia, granulocytopenia, thrombocytopenia, little or no lymphadenopathy, and the presence of hairy or flagellated cells in the blood and bone marrow.
hairy cell leukemia definition: A type of chronic leukemia in which the abnormal white blood cells appear to be covered with tiny hairs when viewed under a microscope.
Hairy Cell Leukemia definition: A rare neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen, and peripheral blood. Most patients are middle-aged to elderly adults and present with splenomegaly and pancytopenia. (WHO, 2001)
Guanidine Hydrochloride definition: The hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. (NCI05)
benzydamine hydrochloride definition: An indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42672&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42672&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1581" NCI Thesaurus)
Benzydamine Hydrochloride definition: An indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties. Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties. (NCI04)
Daunorubicin Hydrochloride definition: The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.
26 further definitions >>
Examples
 

The 1,3-diaryl-imidazolium chlorides IPr·HCl (aryl = 2,6-diisopropylphenyl), IMes·HCl (aryl = 2,4,6-trimethylphenyl) and IXy·HCl (aryl = 2,6-dimethylphenyl), precursors to widely used N-heterocyclic carbene (NHC) ligands and catalysts, were prepared in high yields (81%, 69% and 89%, respectively) by the reaction of 1,4-diaryl-1, 4-diazabutadienes, paraformaldehyde and chlorotrimethylsilane in dilute ethyl acetate solution.

Lukas Hintermann

Beilstein Journal of Organic Chemistry 3 (7), 28 Aug 2007

In contrast to the latter, their synthesis does not involve air-sensitive or pyrophoric organometallic reagents, and they are conveniently stored and used in the form of their air-stable precursors, namely the imidazolium salts IPr·HCl (1,3-bis-{2,6-diisopropylphenyl}imidazolium chloride; 1 ) or IMes·HCl (1,3-bis-{2,4,6-trimethylphenyl}imidazolium chloride; 2 ) (Figure 1 ).

Lukas Hintermann

Beilstein Journal of Organic Chemistry 3 (7), 28 Aug 2007

The present work introduces a simple, reliable and economic synthesis of IPr·HCl ( 1 ), IMes·HCl ( 2 ) and IXy·HCl ( 3 ).

Lukas Hintermann

Beilstein Journal of Organic Chemistry 3 (7), 28 Aug 2007

Thus, the synthesis of IMes·HCl ( 2 ) according to the Arduengo protocol is followed by extensive solvent washes, resulting in a low yield (40%). [ 6 , 7 ] Both the Arduengo and Nolan groups noted that this synthetic protocol cannot be extended to the sterically more hindered IPr·HCl ( 1 ). [ 8 , 9 ] Instead, Arduengo and coworkers found that the reaction of the 1,4-diaryl-1,4-diazadienes (DADs, or glyoxal imines) 4 and 5 with chloromethyl-ethylether (THF, 40°C/16 h or 23°C/5 d) gave pure IPr·HCl ( 1 ) or IMes·HCl ( 2 ) in 47% or 40% yield, respectively (Scheme 2b ). [ 8 ]

Lukas Hintermann

Beilstein Journal of Organic Chemistry 3 (7), 28 Aug 2007

In parallel, Nolan and coworkers obtained IPr·HCl ( 1 ) from DAD 4 and paraformaldehyde in toluene, using HCl/dioxane (4 M) as source of the counter-ion under homogeneous conditions (36 h, r.t., 47% yield) [ 9 , 10 ].

Lukas Hintermann

Beilstein Journal of Organic Chemistry 3 (7), 28 Aug 2007

69 further examples >>
Publications
 
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