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HOXC6 wt Allele definition: Human HOXC6 wild-type allele is located within 12q13.3 and is approximately 14 kb in length. This allele, which encodes homeobox protein Hox-C6, plays a role in both the modulation of transcription by RNA polymerase II and the development of the anterio-posterior axis.
 
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HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12.

D Acampora et al.

Nucleic Acids Research 17 (24), 25 Dec 1989

Results We have measured the rates of nucleotide divergence and indel fixation of three Hox genes, labial ( lab ), proboscipedia ( pb ) and abdominal-A ( abd-A ), and compared them with those of three genes derived by duplication from Hox3 , bicoid ( bcd ), zerknüllt ( zen ) and zerknüllt-related ( zen2 ), and 15 non- Hox genes in sets of orthologous sequences of three species of the genus Drosophila .

Sònia Casillas et al.

BMC Evolutionary Biology 6 (7), 12 Dec 2006

However, it is now known that several arthropod Hox proteins have changed in sequence and/or function, including those encoded by Hox3 [ 11 - 13 ], fushi tarazu ( ftz ) [ 14 ], Ultrabithorax ( Ubx ) [ 15 ] and Antennapedia ( Antp ) [ 16 ].

Sònia Casillas et al.

BMC Evolutionary Biology 6 (7), 12 Dec 2006

In winged insects, including Drosophila , Hox3 and ftz lost their homeotic function, that is, their ability to transform the characteristics of one body part into those of another body part [ 17 , 18 ], and their expression domains are no longer arranged along the anteroposterior axis of the embryo.

Sònia Casillas et al.

BMC Evolutionary Biology 6 (7), 12 Dec 2006

Hox3 gained a novel extraembryonic function, and underwent two consecutive duplications that gave rise to bicoid ( bcd ), zerknüllt ( zen ) and zerknüllt-related ( zen2 ).

Sònia Casillas et al.

BMC Evolutionary Biology 6 (7), 12 Dec 2006

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