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MSX1 Gene definition: This gene is involved in transcriptional repression and embryogenesis.
Homeobox Protein MSX-1 definition: Encoded by human MSX1 Gene (MSH Family), 297-aa 31-kDa nuclear Homeobox Protein MSX-1 is a transcription repressor involved in craniofacial development, odontogenesis, and perhaps limb-pattern formation. MSX1 Defects cause hypodontia (HYD1), Witkop syndrome, nonsyndromic orofacial cleft (OFC) and possibly (deleted in) Wolf-Hirschorn syndrome (WHS). (NCI)
MSX1 wt Allele definition: Human MSX1 wild-type allele is located within 4p16.3-16.1 and is approximately 4 kb in length. This allele, which encodes homeobox protein MSX-1, is involved in both the repression of transcription by RNA polymerase II and the development of teeth and limbs.
 
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