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homeobox gene definition: genes that code for DNA binding genetic regulatory proteins in a variety of organisms, so named for the homeotic genes of Drosophila.
Genes, Homeobox definition: Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS.
Homeobox Gene definition: Highly conserved DNA sequences which have been identified in specific gene transcripts ranging from those of Drosophila melanogaster to mouse and human. Homeobox genes function, in part, to generate DNA-binding proteins with an evolutionary conserved approximately 60-residue sequence (HOMEODOMAIN PROTEINS).
T-Cell Leukemia Homeobox Protein 1 definition: a DNA-binding nuclear transcription factor. HOX11 is an orphan homeobox gene since it is located at a site outside the 4 mammalian HOX clusters. Whereas the orthodox HOX genes encode a combinatorial system of positional specification along the anterior-posterior axis of the embryo, the function of orphan homeobox genes is less well understood. Essential for the survival of splenic precursors during organogenesis. (from OMIM)
HOXC6 Gene definition: This gene plays a role in transcriptional repression, morphogenesis and differentiation.
Homeobox Protein Hox-A10 definition: Encoded by human HOXA10 Gene (ABD-B Family) and expressed spatially/temporally in posterior domains during genitourinary development, 496- and 494-amino acid 41-kD Homeobox Protein A10 isoforms are inhibitory transcription factors, containing a common DNA-binding homeobox domain, that may regulate morphogenesis and differentiation by providing anterior-posterior positional identity. HOXA10 protein is also expressed in adult endometrium during early pregnancy. Bound to 5-prime AA[AT]TTTTATTAC 3-prime DNA, HOXA10 may mediate progesterone regulation of uterine EP3 and EP4. HOXA10 also appears to regulate hematopoietic lineage commitment. (from LocusLink, Swiss-Prot, OMIM, and NCI)
HOXA10 Gene definition: This gene is involved in transcriptional regulation and in the regulation of endometrial development.
Homeobox Protein MSX-1 definition: Encoded by human MSX1 Gene (MSH Family), 297-aa 31-kDa nuclear Homeobox Protein MSX-1 is a transcription repressor involved in craniofacial development, odontogenesis, and perhaps limb-pattern formation. MSX1 Defects cause hypodontia (HYD1), Witkop syndrome, nonsyndromic orofacial cleft (OFC) and possibly (deleted in) Wolf-Hirschorn syndrome (WHS). (NCI)
HOXC6 wt Allele definition: Human HOXC6 wild-type allele is located within 12q13.3 and is approximately 14 kb in length. This allele, which encodes homeobox protein Hox-C6, plays a role in both the modulation of transcription by RNA polymerase II and the development of the anterio-posterior axis.
HOXA10 wt Allele definition: Human HOXA10 wild-type allele is located within 7p15-p14 and is approximately 10 kb in length. This allele, which encodes homeobox protein Hox-A10, is involved in both the modulation of the transcriptional activity of RNA Polymerase II and the development of the anterio-posterior axis.
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