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ICR BR Mouse definition: Derived from Rockefeller Swiss mice that were disseminated to the Institute of Cancer Research in Philadelphia (1948). The ICR BR strain is a general purpose model that is employed in safety and efficacy testing, aging studies, pseudo pregnancy, and as a surgical model.
 
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Our web tool iCR (identify Conserved target of a Regulon) makes use of this fact and identify conserved targets of a regulatory protein. iCR is a special refined extension of our previous tool PredictRegulon- that predicts genome wide, the potential binding sites and target operons of a regulatory protein in a single user selected genome.

Sarita Ranjan et al.

Nucleic Acids Research 34 (Web Server issue), 01 Jul 2006

Like PredictRegulon, the iCR accepts known binding sites of a regulatory protein as ungapped multiple sequence alignment and provides the potential binding sites.

Sarita Ranjan et al.

Nucleic Acids Research 34 (Web Server issue), 01 Jul 2006

In order to achieve this, iCR makes use of Cluster of Orthologous Group (COG) indices for the genes.

Sarita Ranjan et al.

Nucleic Acids Research 34 (Web Server issue), 01 Jul 2006

This tool analyses the upstream region of all user-selected prokaryote genome and gives the output based on conservation target orthologs. iCR also reports the Functional class codes based on COG classification for the encoded proteins of downstream genes which helps user understand the nature of the co-regulated genes at the result page itself. iCR is freely accessible at .

Sarita Ranjan et al.

Nucleic Acids Research 34 (Web Server issue), 01 Jul 2006

We describe here iCR (identify Conserved target of a Regulon), a web server tool, for identification of conserved high priority targets of a regulatory protein from heterologous sequence data of prokaryotes (which includes regulatory sequences of genes and their orthologs in other species) where the user can easily distinguish biologically important motifs from background noise based on their cross species conservation.

Sarita Ranjan et al.

Nucleic Acids Research 34 (Web Server issue), 01 Jul 2006

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