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Glucagonoma definition: An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.
glucagonoma definition: (GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes.
Pancreatic Glucagon Producing Tumor definition: A usually malignant, glucagon-secreting tumor of the pancreatic alpha cells. It may be associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia. Almost 25% of patients experience thromboembolic complications, and 50% have liver metastases at the time of diagnosis.
Insulinoma definition: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
Pancreatic Insulin Producing Tumor definition: A usually benign, well circumscribed neoplasm arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin.
Islets of Langerhans definition: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
pancreatic islet definition: irregular microscopic structures, varying from a few to hundreds of cells, scattered throughout the pancreas and comprising its endocrine portion; cell types include: alpha, secreting glucagon; beta, secreting insulin; delta, secreting somatostatin; and PP, secreting pancreatic polypeptide.
islets of Langerhans definition: (EYE-lets of LANG-er-hanz) Cells in the pancreas that produce hormones (including insulin).
Pancreatic Somatostatin Producing Tumor definition: A usually malignant, somatostatin secreting endocrine neoplasm, arising from the delta cells of the pancreas. It is associated with diabetes mellitus, hypochlorhydia, gallbladder disease, diarrhea, steatorrhea, anaemia, and weight loss.
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