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Carcinoma, Large Cell definition: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
large cell carcinomas definition: (kar-sin-O-mas) A group of lung cancers in which the cells are large and look abnormal when viewed under a microscope.
Large Cell Carcinoma definition: A malignant epithelial neoplasm composed of large, atypical cells.
Large Cell Lung Carcinoma definition: A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection.
Recurrent Large Cell Lung Carcinoma definition: The re-emergence of large cell lung carcinoma after a period of remission. (NCI05)
Stage I Large Cell Lung Carcinoma definition: A non-small cell lung cancer (NSCLC), histologically classified as large cell carcinoma. No regional lymph node or distant metastases. Tumor size and aggressiveness vary. Subclassified as Stage IA (T1,N0,M0) or Stage IB (T2,N0,M0). T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases. T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.
Stage II Large Cell Lung Carcinoma definition: A non-small cell lung cancer (NSCLC), histologically classified as large cell carcinoma. No distant metastasis. Various extents of tumor size and aggressiveness, and of regional lymph node metastasis. Subclassified as Stage IIA (T1,N1,M0) or Stage IIB (either T2,N1,M0 or T3,N0,M0). N0: no regional lymph node metastasis. N1: regional metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, and intrapulmonary nodes including involvement by direct extension of the primary tumor. T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus. T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung. T3: tumor (of any size) directly invades any of the following: chest wall (including superior sulcus tumors), diaphragm, mediastinal pleura, parietal pericardium; or tumor in the main bronchus less than 2 cm distal to the carina but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung.
Stage III Large Cell Lung Carcinoma definition: A non-small cell lung cancer (NSCLC), histologically classified as large cell carcinoma. No distant metastasis. Various extents of tumor size and aggressiveness, and of regional lymph node metastasis. Subclassified as Stage IIIA (T1,N2,M0; T2,N2,M0; T3,N1,M0; T3,N2,M0) or Stage IIIB (AnyT,N3,M0; T4,AnyN,M0). N1: regional metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, and intrapulmonary nodes including involvement by direct extension of the primary tumor. N2: Metastasis to ipsilateral mediastinal and/or subcarinal lymph node(s). N3: Metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s). T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus. T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung. T3: tumor (of any size) directly invades any of the following: chest wall (including superior sulcus tumors), diaphragm, mediastinal pleura, parietal pericardium; or tumor in the main bronchus less than 2 cm distal to the carina but without involvement of the carina; or associated atelectasis or obstructive pneumonitis of the entire lung. T4: tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, esophagus, vertebral body, carina; or separate tumor nodules in the same lobe; or tumor with a malignant pleural effusion.
Stage IV Large Cell Lung Carcinoma definition: A non-small cell lung cancer (NSCLC), histologically classified as large cell cell carcinoma. Distant metastasis is present. Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).
Large Cell Neuroendocrine Carcinoma definition: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
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