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Chemokine CCL3 definition: A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.
Small Inducible Cytokine A3 definition: Macrophage Inflammatory Protein-1 is a monokine involved in the acute inflammatory recruitment and activation of polymorphonuclear leukocytes. There are two protein components of MIP1, alpha and beta. MIP-1 alpha has been identified as an early G0/G1 switch gene in blood mononuclear cells. RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells. (from OMIM 182283 and NCI)
Chemokine (C-C Motif) Receptor 1 definition: Chemokine (C-C Motif) Receptor 1, encoded by the CCR1 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite. (From LocusLink and NCI)
Small Inducible Cytokine A3-Like 1 definition: Encoded by human CCL3L1 Gene (Intercrine Beta Family), secreted 93-aa 10-kD (precursor) Small Inducible Cytokine A3 Like 1 is a putative chemokine involved in immunoregulatory and inflammatory processes. (NCI)
Small Inducible Cytokine A3-Like 1 definition: Chemokine (C-C Motif) Ligand 3-Like 1, encoded by the CCL3L1 gene, belongs to an intercrine beta family. This signaling cytokine attracts and activates leukocytes, and has an anti-HIV-1 activity. It is implicated in cell cycle and signal transduction.
Recombinant Macrophage Inflammatory Protein-1 Alpha definition: A recombinant therapeutic agent which is chemically identical to or similar to endogenous macrophage inflammatory protein-1, a member of the CC chemokine family produced by activated macrophages. Macrophage inflammatory protein-1 alpha activates granulocytes and induces pro-inflammatory cytokine synthesis. The addition of macrophage inflammatory protein-1 alpha to a vaccine consisting of a DNA immunogen or a pro-inflammatory peptide may enhance vaccine-induced host immune anti-tumor responses. (NCI04)
CCL3L1 wt Allele definition: Human CCL3L1 wild-type allele in the vicinity of 17q21.1 and is approximately 2 kb in length. This allele, which encodes small inducible cytokine A3-Like 1 protein, is involved in leukocyte attraction and activation. CCL3L1 may play a role in both the cell cycle and signal transduction.
CCR1 wt Allele definition: Human CCR1 wild-type allele is located within 3p21 and is approximately 6 kb in length. This allele, which encodes C-C chemokine receptor type 1 protein, is involved in signal transduction and recruitment of effector immune cells to the site of inflammation. This allele has purported roles in host protection from inflammatory responses, and susceptibility to virus and parasite invasion.
 
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