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These SNPs are in arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP), leukotriene C4 synthase (LTC4S), cysteinyl leukotriene receptor 1 (CYSLTR1) and cysteinyl leukotriene receptor 2 (CYSLTR2) genes.

Hasan Al-Shemari et al.

BMC Medical Genetics 9 (7), 26 Mar 2008

The LO pathway for synthesizing cysLTs has several steps, and distinct enzymes are involved in each steps, namely arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP or FLAP), and leukotriene C4 synthase (LTC4S) [ 21 ].

Hasan Al-Shemari et al.

BMC Medical Genetics 9 (7), 26 Mar 2008

LO, lipoxygenase pathway; COX, cyclo-oxygenase pathway; ALOX5, arachidonate 5-lipoxygenase; ALOX5AP, arachidonate 5-lipoxygenase-activating protein; LTC4S, leukotriene C4 synthase; CYSLTR1, cysteinyl leukotriene receptor 1; CYSLTR2, cysteinyl leukotriene receptor 2.

Hasan Al-Shemari et al.

BMC Medical Genetics 9 (7), 26 Mar 2008

Gene (chr) SNPs MAF Minor allele HWE p value Case, Control Ratios** p value ALOX5AP (13) rs12430915 0.08 C 0.200 38:378, 26:346 0.271 rs4769870 0.16 T 0.080 353:61, 269:61 0.170 rs4076128 0.30 C 0.439 290:124, 255:111 0.909 rs11616333 0.05 G 0.558 22:396, 19:353 0.922 rs4769055 0.33 A 0.187 143:275, 120:252 0.561 rs9578196 0.10 T 0.408 380:38, 326:42 0.283 rs4293222 0.37 C 0.930 161:257, 134:236 0.505 rs12429692 0.26 T 1.000 118:300, 88:284 0.144 rs10162089 0.49 T 0.828 217:197, 184:186 0.453 rs4254165 0.28 C 0.928 302:114, 264:108 0.612 rs4356336 0.42 C 1.000 242:176, 208:154 0.902 rs17612127 0.08 T 0.847 40:376, 21:343 0.046 rs9506352 0.34 T 0.300 278:138, 242:128 0.674 rs9579648 0.15 C 0.317 68:350, 52:320 0.371 rs9579649 0.07 T 0.330 28:388, 24:348 0.875 rs9315051 0.08 C 1.000 33:385, 26:346 0.629 rs4420371 0.25 C 0.842 107:311, 93:277 0.882 rs4466940 0.20 T 0.295 85:329, 60:256 0.604 rs9578200 0.17 T 0.014 352:66, 307:65 0.525 rs9285076 0.22 T 0.133 326:92, 289:83 0.919 rs9670198 0.04 A 0.168 401:15, 329:13 0.887 rs4319601 0.41 T 0.064 241:163, 209:143 0.938 rs4769063 0.13 T 1.000 365:51, 322:50 0.621 rs4238139 0.28 C 0.028 117:301, 99:265 0.805 ALOX5 (10) rs3824612 0.38 T 0.263 273:145, 220:152 0.074 rs3780894 0.17 C 0.789 85:333, 52:320 0.019 rs7099684 0.19 A 0.456 82:332, 65:301 0.466 rs7919239 0.23 A 0.392 101:313, 79:293 0.293 rs2115819 0.47 C 0.414 195:219, 152:180 0.720 rs11239523 0.16 C 0.831 71:345, 55:317 0.383 rs4948672 0.46 C 0.512 203:215, 161:211 0.137 rs12264801 0.45 T 0.028 230:188, 202:168 0.904 rs3780901 0.33 C 0.440 143:271, 116:250 0.400 rs2279435 0.43 C 0.707 187:231, 156:216 0.428 rs1565096 0.23 C 0.094 323:95, 283:89 0.691 rs1487562 0.21 T 0.381 97:321, 69:301 0.117 rs2291427 0.30 T 0.870 298:120, 257:115 0.498 rs7393696 0.38 A 0.394 256:154, 207:135 0.591 rs7089063 0.24 A 0.478 112:304, 61:233 0.059 CYSLTR2 (13) rs2406939 0.36 C 0.948 152:266, 130:242 0.678 rs11617224 0.11 C 1.000 375:43, 329:41 0.719 rs6420296 0.08 C 1.000 389:29, 337:33 0.303 rs7335898 0.06 G 0.790 28:390, 18:336 0.345 rs9285169 0.09 T 0.136 43:373, 26:334 0.129 rs9595961 0.48 C 0.994 203:215, 175:195 0.722 rs17072059 0.04 T 0.784 407:11, 353:17 0.137 rs7330127 0.44 A 1.000 189:229, 155:207 0.501 rs2407249 0.21 C 0.129 88:330, 74:298 0.687 rs9568087 0.29 A 0.315 299:117, 254:108 0.600 rs12184704 0.07 C 0.057 33:385, 21:339 0.259 CYSLTR1 (X)* rs321090 0.23 C 0.605 247:60, 207:81 0.014 rs321007 0.30 C 0.916 224:84, 192:96 0.107 rs321006 0.13 T 0.423 42:266, 37:252 0.764 LTC4S (5) rs730012 0.29 C 0.403 126:292, 103:269 0.448 rs2291418 0.04 T 0.316 399:15, 347:19 0.284 rs166624 0.17 A 1.000 77:341, 56:316 0.207 HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency.

Hasan Al-Shemari et al.

BMC Medical Genetics 9 (7), 26 Mar 2008

In contrast, the current study does not corroborate the previous association between SNP LTC4S-rs730012 (also known as -444A/C) and allergic rhinitis [ 28 ].

Hasan Al-Shemari et al.

BMC Medical Genetics 9 (7), 26 Mar 2008

 
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