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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization definition: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Matrix-Assisted Laser Desorption Ionization Mass Spectrometry definition: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample- matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis. (CHI)
matrix assisted laser desorption ionization definition: soft ionization technique which produces quasimolecular ions of large organic molecules up to several 100 kDa molecular mass.
Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry definition: In MALDI-TOF, a laser pulse is fired into a protein or peptide sample contained in a light-absorbing matrix. A small explosion vaporizes and ionizes the sample. In the presence of a high electric field, peptide ions are accelerated down an evacuated flight tube. Because large particles travel more slowly than small ones, the masses of the ionized particles are determined by measuring their arrival time at the end of the tube
 
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