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MAP Kinase Kinase Kinase 1 definition: A 195-kDa MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It is found localized in the CYTOSKELETON and can activate a variety of MAP kinase-dependent pathways.
MEKK1 Protein definition: Encoded by MAP3K1 Gene (MAP3K Family), MEKK1 Protein is pivotal in the Ser/Thr phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
 
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