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MAP Kinase Kinase Kinase 4 definition: A 180-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 4 and MAP KINASE KINASE 6.
HGK Protein definition: Encoded by MAP4K4 Gene (SER/THR Family, STE20 Subfamily), ubiquitous HGK Protein contains a CNH domain and an N-terminal catalytic domain with 11 kinase subdomains; it shares 47-48% amino acid identity with HPK1 and GCK catalytic domains. Of 5 tissue alternative isoforms, variant 2 is longest and contains proline-rich domains. Variants 1 and 3 lack two coding segments and variant 1 contains an extra coding segment. In response to environmental stress and cytokines such as TNFA, HGK appears to act through MAP3K7, MAP2K4, and MAP2K7 cascades to activate JNK and the c-JUN N-terminal transcriptional pathway. HGK may interact with the SH3 domain of NCK adapter proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)
 
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