dict.md logo
Choose languages of interest
SELECT >>
English
German
Advertisement:
Definition
 
enEnglish
Methylselenocysteine definition: A naturally occurring organoselenium compound found in many plants, including garlic, onions, and broccoli, with potential antioxidant and chemopreventive activities. Se-Methyl-seleno-L-cysteine (MSC) is an amino acid analogue of cysteine in which a methylselenium moiety replaces the sulphur atom of cysteine. This agent acts as an antioxidant when incorporated into glutathione peroxidase and has been shown to exhibit potent chemopreventive activity in animal models.
MSC Gene definition: This gene is involved in the repression of transcription. It may also play a role in the regulation of B-cell differentiation.
Musculin definition: The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
MSC wt Allele definition: Human MSC wild-type allele is located in the vicinity of 8q21 and is approximately 3 kb in length. This allele, which encodes musculin protein, is involve in both the modulation of transcription by RNA polymerase II and antigen-dependent differentiation in B cells.
 
Examples
 

Previous studies have reported that mesenchymal stem cells (MSC) may be isolated from the synovial membrane by the same protocol as that used for synovial fibroblast cultivation, suggesting that MSC correspond to a subset of the adherent cell population, as MSC from the stromal compartment of the bone marrow (BM).

Farida Djouad et al.

Arthritis Research & Therapy 7 (6), 2005

The aims of the present study were, first, to better characterize the MSC derived from the synovial membrane and, second, to compare systematically, in parallel, the MSC-containing cell populations isolated from BM and those derived from the synovium, using quantitative assays.

Farida Djouad et al.

Arthritis Research & Therapy 7 (6), 2005

Fluorescent-activated cell sorting analysis revealed that both populations were negative for CD14, CD34 and CD45 expression and that both displayed equal levels of CD44, CD73, CD90 and CD105, a phenotype currently known to be characteristic of BM-MSC.

Farida Djouad et al.

Arthritis Research & Therapy 7 (6), 2005

Comparable with BM-MSC, such MSC-like cells isolated from the synovial membrane were shown for the first time to suppress the T-cell response in a mixed lymphocyte reaction, and to express the enzyme indoleamine 2,3-dioxygenase activity to the same extent as BM-MSC, which is a possible mediator of this suppressive activity.

Farida Djouad et al.

Arthritis Research & Therapy 7 (6), 2005

Using quantitative RT-PCR these data show that MSC-like cells from the synovium and BM may be induced to chondrogenic differentiation and, to a lesser extent, to osteogenic differentiation, but the osteogenic capacities of the synovium-derived MSC were significantly reduced based on the expression of the markers tested (collagen type II and aggrecan or alkaline phosphatase and osteocalcin, respectively).

Farida Djouad et al.

Arthritis Research & Therapy 7 (6), 2005

38 further examples >>
Publications
 
0 publications