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Thrombopoietin definition: A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
thrombopoietin definition: A colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood forming) agents.
Thrombopoietin definition: Thrombopoietin is a lineage-restricted, glycoprotein growth factor ligand for the MPL receptor with selective action on megakaryopoiesis and platelet production. THPO has little direct effect on erythroid progenitor cells but may enhance erythropoiesis indirectly by preventing early erythroid progenitor cells from undergoing apoptotic cell death. (from OMIM 600044 and NCI)
Thrombopoietin Receptor definition: Thrombopoietin receptor (635 aa, 71 kD) is a cell division process protein that is encoded by the human MPL gene and has roles in cell proliferation and signal transduction.
MPL Gene definition: This gene plays a regulatory role in megakaryocytopoiesis and platelet formation.
THPO Gene definition: This gene plays a role in promoting megakaryocytopoiesis, the cellular development process that leads to platelet production.
THPO wt Allele definition: Human THPO wild-type allele is located within 2p13 and is approximately 107 kb in length. This allele, which encodes thrombopoietin protein, plays a role in megakaryocyte proliferation and maturation, as well as thrombopoiesis.
MPL wt Allele definition: Human MPL wild-type allele is located in the vicinity of 1p34.2 and is approximately 46 kb in length. This allele, which encodes thrombopoietin receptor protein, plays a role in megakaryocytopoiesis, hematopoesis and platelet formation. Defects in the gene cause congenital amegakaryocytic thrombocytopenia.
 
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