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The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?

Josef S Smolen et al.

Arthritis Research & Therapy , 2008

Ventricular Free Wall Rupture: Ten Year Survival After Surgical Repair: ... cases is about 2%. [1] Clinical markers suggesting free wall ...

Richard A Leff et al.

The Open Cardiovascular Medicine Journal , 22 Jan 2008

Computational Lipidology: Predicting Lipoprotein Density Profiles in Human Blood Plasma: ... infarction. However, clinical markers beyond “bad” and “good” ...

Katrin Hübner et al.

PLoS Computational Biology , 01 May 2008

Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts: ... correlated with clinical markers of disease ...

Dirk Pohlers et al.

Arthritis Research & Therapy , 2007

Statin use is associated with fewer periodontal lesions: A retrospective study: ... of statin use and clinical markers of chronic ...

Otso Lindy et al.

BMC Oral Health , 15 May 2008

Pruritus is a common feature in sheep infected with the BSE agent: ... The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist. Results ...

Timm Konold et al.

BMC Veterinary Research , 29 Apr 2008

Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy: ... of radiotherapy. As clinical parameters are insufficient for identifying these two groups of patients, we investigated whether gene expression profiling would add further information. Methods We performed gene expression analysis (oligonucleotide arrays, 26,824 reporters) on 143 patients with lymph node-negative disease and tumor-free margins. A support vector machine was employed to build classifiers using leave-one-out cross-validation. Results Within the estrogen receptor-positive (ER + ) subgroup, the gene expression profile clearly distinguished patients with local recurrence after radiotherapy (n = 20) from those without local recurrence (n = 80 with or without radiotherapy). The receiver operating characteristic (ROC) area was 0.91, and 5,237 of 26,824 reporters had a P value of less than 0.001 (false discovery rate = 0.005). This gene expression profile provides substantially added value to conventional clinical markers (for example, age, ...

Emma Niméus-Malmström et al.

Breast Cancer Research : BCR , 2008

Utility of the modified ATP III defined metabolic syndrome and severe obesity as predictors of insulin resistance in overweight children and adolescents: a cross-sectional study: ... are considered as clinical markers for IR. Objective ...

Sarita Dhuper et al.

Cardiovascular Diabetology , 14 Feb 2007

Serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population.: ... seminal, hormonal, or clinical markers of male reproductive ...

Jonas Richthoff et al.

Environmental Health Perspectives , 01 Apr 2003

Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites: ... the analysis of fresh clinical isolates. The data presented here indicate that there is no promiscuous transcription of var genes at the individual cell level and that it is possible to correlate dominant transcripts with adhesion phenotype and clinical markers of malaria severity.

Madeleine Dahlbäck et al.

Malaria Journal , 12 Jun 2007

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